COPD, HEAD&NECK CANCER,SCREENING
Conditions
Brief summary
Head and neck cancers usually occur in patients who have a history of long tobacco use. Chronic obstructive pulmonary disease (COPD) is a chronic progressive disease of the airways and lung parenchyma that is also associated with exposure to tobacco. COPD and head & neck cancer share a common environmental risk factor in cigarette smoke exposure. the investigators hypothesize that patients with chronic lung disease related to smoking have a higher risk to develop cancer in the head and neck. The investigators designed a study to assess the prevalence of cancer and pre-cancer disease in the head & neck in patients with chronic lung disease. the investigators will examine patients with and without a history of smoking and chronic lung disease in order to determine the prevalence of head and neck cancer in the different groups. The patients who will be included in the study will undergo comprehensive evaluation of their lung function and voice performance. This study is a joint effort of the Pulmonology Institute and the Department of Otolaryngology, Head & Neck Surgery in Israel and the Netherlands.
Interventions
OTHERStroboscopic nasopharyngeal laryngoscopy
Sponsors
Hadassah Medical Organization
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
1. group of adult COPD patients. 2. Adult patients with smoking history and no clinical manifestation of COPD who will be recruited form the institute of pulmonary medicine and the otolaryngology outpatient clinic. 3. Adult patients with lung disease unrelated to smoking, i.e. bronchial asthma who will be recruited from the institute of pulmonary medicine
Exclusion criteria
1. Patients with an acute disease or COPD exacerbation 2. Pregnant patients 3. Patients who were intubated ≤3 months prior to inclusion 4. Patients with a medical history of surgical intervention in the upper airway 5. Patients with a medical history of malignant disease in the upper airway 6. Patients who underwent radiotherapy of head and neck
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the primary outcome measure is the number of patients with malignant tumors and pre-malignant lesions of the head & neck | participants will be followed for the duration of hospital stay, an expected average of one week | prevalence of malignant tumors and pre-malignant lesions of the head & neck in general, and the larynx in particular, is significantly increased in the COPD patient population in comparison to patients with history of smoking without clinical presentation of COPD and patients with no history of smoking. |
Contacts
Primary ContactTali Zemer- Landau
Outcome results
None listed