Type 2 Diabetes
Conditions
Keywords
Type 2 diabetes, Interval training, Insulin resistance, fat metabolism
Brief summary
The overall objective of this study is to examine the blood flow in the thigh muscles and sugar metabolism before and after 8 weeks of high intensity interval training (HIIT) on a bicycle ergometer in patients with type 2 diabetes (T2D) and matched controls. The following parameters are included in the assessment: * Sugar Metabolism * Muscle and fat mass * The blood flow at rest around the thigh muscles * Oxygen uptake test on a bicycle ergometer and 5 km time trial
Detailed description
Type 2 diabetes (T2D) can be defined as a bihormonal metabolic disorder characterised by insufficient insulin secretion and abnormal glucagon secretion. It is however well established that physical activity per se improves glucose and may postpone or even slow down in the diabetic population. Glycaemic control may be improved more by high intensity interval training than by intensities from existing recommended guidelines. Additionally, there seems to be accumulating evidence that high intensity interval training induces increased overall fat and abdominal fat mass loss as opposed to traditional continuous endurance training Therefore we hypothesise that 3 weekly sessions of high intensity interval training (10×60 sec. at an intensity inducing 90% of maximal heart frequency with a recovery of 60 sec. between each bout) over 8 weeks improves overall glycaemic control (glucose, insulin and glucagon), inflammatory status (interleukins, cytokines, chemokines and cell adhesion molecules) and blood flow (NO and PGI2 vasodilatory capabilities).
Interventions
OTHERPhysical training
Performed supervised high intensity interval training 3 times a week over 8 weeks on a bicycle ergometer (with watt meter). During the training period, the trainee individually established program, each time with 10 × 60 sec. workout (interspersed with 60 sec. break) corresponding to a force which during the test cycle induces \ 90% of the maximum heart rate. The time spent per session is expected to last \ 25 minutes.
Sponsors
Aarhus University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Type 2 diabetes or matched healthy controls. T2D subject only : HbA1c \> 7,3. All subjects have an age between 40-65 years and a body mass index between 25-40 kg/m2. Both genders is allowed
Exclusion criteria
* Severe diseases /immobility
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Oral Glucose tolerance test (OGTT) | baseline and 8 weeks | Change from baseline and 8 weeks in glucose/insulin response from a 2.5 hours oral glucose tolerance test (iAUC) after 8 weeks training |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Physical fitness | baseline and 8 weeks | Change from baseline and after 8 weeks in physical fitness level (mL/min x kg) measured with submaximal test using a bicycle ergometer after 8 weeks interval training . |
Other
| Measure | Time frame | Description |
|---|---|---|
| Muscle and fat mass | baseline and 8 weeks | Change from baseline and 8 weeks in Muscle and fat mass (DEXA Scan) |
| blood flow | baseline and 8 weeks | Change from baseline and 8 weeks in blood flow at rest around the thigh muscles (Ultra Sound technic) |
Countries
Denmark
Outcome results
None listed