Neonatal Respiratory Distress Syndrome
Conditions
Keywords
Lung fluid absorption disorders, Neonatal respiratory distress syndrome, Single nucleotide polymorphism, SCNN1A
Brief summary
Lung fluid absorption disorders are largely mediated by transepithelial Na+ reabsorption through alpha epithelial sodium channels (α-ENaCs) in alveolar epithelial cells. Increasing evidence has demonstrated that these lung disorders might be an important cause of neonatal respiratory distress syndrome (NRDS) by influencing gas exchange or surfactant function, particularly in near-term and term infants. The SCNN1A gene, which encodes the α-ENaC, might predispose infants to NRDS. To explore whether the single-nucleotide polymorphisms (SNPs) of SCNN1A are associated with NRDS, we conducted a case-control study to investigate the NRDS-associated loci in Han Chinese infants. Seven target SNPs were selected from the SCNN1A gene and were genotyped using the improved multiplex ligase detection reaction (iMLDR).
Interventions
OTHERno intervention
no intervention
Sponsors
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Minutes to 28 Days
Healthy volunteers
Yes
Inclusion criteria
* Newborns with RDS
Exclusion criteria
* The infants were excluded if they had any congenital malformation, inherited metabolic abnormalities, intrauterine infection, Rh/Rh incompatibility, pneumonia, pulmonary hypertension, meconium aspiration syndrome, or asphyxia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Genotype distributions of target SNPs in RDS group and Control group | within 28 days after birth | Compare the genotype and allele frequencies of target SNPs between RDS group and the control group |
Countries
China
Outcome results
None listed