Anorexia
Conditions
Brief summary
This prospective pilot study will compare adolescents with restrictive anorexia nervosa who participated for 3 months at olfactory workshops, patients who did not, and healthy patients.The groups will be evaluated before the workshops and after three months, with the wanting score after olfactory stimuli and with serum oxytocin level.
Detailed description
The restrictive anorexia nervosa (AN) in adolescents is an eating disorder with decreased desire to eat (wanting) following olfactory stimulation. Oxytocin is an hormone involved in the neuromodulation of eating behavior, but also involved in olfactory perception in schizophrenia patients, and in social cognition in patients with autism. Its plasma level was found low in anorexic patients compared to control subjects. Because of the similarity in disorders of social cognition between these three diseases, we assume that the desire to eat evoked by olfactory perception varies with the plasma oxytocin levels. With a prospective pilot study we will compare patients with AN who participated for 3 months at olfactory workshops, AN patients who did not, and healthy patients. The groups will be evaluated before the workshops and after three months, with the wanting score after olfactory stimuli and with serum oxytocin level. One application of this study will be the use of ocytocyne nasal spray to increase the eating desire and to allow weight regain
Interventions
OTHERolfactory workshop
olfactory workshop
OTHERother workshop
other workshop: discussion group, dance and body Expression
OTHERNo intervention
control group
Sponsors
Fondation Lenval
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
11 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* Medical-Review * Female or male -Sexe, * 11 to 18 years * Anorexia nervosa diagnosed according to the criteria DSM V * Outpatient care or hospitalization * Be able to answer the clinicals evaluations questionnaires * Affiliated to social security * Consentement of the legal representative and the patient
Exclusion criteria
* Somatic comorbidity associated with diabetes, celiac disease, brain tumor * Intolerance odors, predisposed to develop asthma and / or respiratory allergies Pathologie chronic rhino-sinus * Hyposmiques or anosmic * Patients not of an inclusion criteria
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Score Wanting to olfactory stimuli | at 3 months |
Secondary
| Measure | Time frame |
|---|---|
| Oxytocin serum level | at 3 months |
| Body mass index | at 3 months |
| Scores to clinical scales | at 3 months |
| Scores to hedonicity scale | at 3 months |
| Scores to liking-wanting tests | at 3 months |
Countries
France
Outcome results
None listed