Esophageal Motility in Eosinophilic Esophagitis Evaluated by High Resolution Manometry.

Esophageal Motility in Eosinophilic Esophagitis Evaluated by High Resolution Manometry - Effect on Esophageal Motility of Standard Therapy.

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02331849

Acronym

HIMEOS

Enrollment

Registered

2015-01-06

Start date

2013-10-31

Completion date

Unknown

Last updated

2015-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Eosinophilic Esophagitis

Keywords

Eosinophilic esophagitis (EoE), GERD, esophageal motility

Brief summary

Esophageal Motility in eosinophilic esophagitis will be evaluated by High Resolution Manometry before and after medical treatment - motility is suspected to change/improve after therapy.

Detailed description

After identification of eosinophilic inflammation of the esophagus -\> differentiation between GERD and eosinophilic esophagitis (via pH/MII-measurements or PPI-trial) -\> High-resolution manometry (HRM) for evaluation of esophageal motility in patients with eosinophilic esophagitis (exclusion of GERD-patients)-\> initiation of budesonide-therapy -\> after eight weeks of therapy reevaluation of esophageal motility by HRM

Interventions

DEVICEHigh resolution manometry (HRM)

High resolution manometry of the esophagus

Study design

Allocation

Intervention model

SINGLE_GROUP

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

• patients with eosinophilic inflammation of the esophagus

Exclusion criteria

* refusal to participate in study * pregnancy * eosinophilic gastroenteritis * Achalasia * contraindication for gastroscopy / HRM / 24-h-pH/Impedance-monitoring * contraindication for therapy with budesonide * eosinophilic inflammation due to GERD

Design outcomes

Primary

Measure	Time frame	Description
Improvement of esophageal motility (IBP) measureable in high resolution manometry (HRM)	Two months	Average maximum intra-bolus-pressure (IBP) \[mmHg\] before and after therapy

Secondary

Measure	Time frame	Description
Improvement of esophageal motility (e.g. specified in the chicago classification) represented in high resolution manometry (HRM)	Two months	weak peristalsis with small/large breaks, frequently failes peristalsis, absent peristalsis, hypertensive peristalsis, rapid contractions with normal latency, functional EGJ-obstruction, panesophageal pressurizations, compartimentalized pressurizations;
Endoscopic evaluation of inflammation before/after therapy	Two months	Endoscopic assessment of esophageal signs of eosinophilic esophagitis (white exsudates, furrows, edema, rings, crepe paper, stricture
Symptoms before/after therapy	Two months	Evaluation of symptoms via questionnaire before/after therapy

Countries

Germany

Contacts

Primary ContactSimon Nennstiel

simon.nennstiel@lrz.tum.de+49 89 4140 5055

Backup ContactChristoph Schlag

christoph.schlag@lrz.tum.de+49 89 4140 5055

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026