Traumatic Brain Injury
Conditions
Keywords
Traumatic Brain Injury, Executive function difficulties, Transcranial direct current stimulation
Brief summary
Traumatic brain injury (TBI) particularly affects the frontal lobes and patients often suffer from executive dysfunction and behavioral disturbances. These types of injuries often involve axonal damage to pre frontal brain areas, which mediate various cognitive and behavioral functions. Dorsolateral prefrontal circuit lesions cause executive dysfunction, orbitofrontal circuit lesions lead to personality changes characterized by disinhibition and anterior cingulate circuit lesions present with apathy. Patients who suffered traumatic frontal lobe damage often demonstrate a lasting, profound disturbance of emotional regulation and social cognition. Weak transcranial direct current stimulation (tDCS) induces persisting excitability changes in the human motor cortex. this effect depends on the stimulation polarity and is specific to the site of stimulation. Interacting with cortical activity, by means of cortical stimulation, can positively affect the short-term cognitive performance and improve the rehabilitation potential of neurologic patients. In this respect, preliminary evidence suggests that cortical stimulation may play a role in treating aphasia, unilateral neglect, and other cognitive disorders. Several possible mechanisms can account for the effects of tDCS and other methods on cognitive performance. They all reflect the potential of these methods to improve the subject's ability to relearn or to acquire new strategies for carrying out behavioral tasks. It was also found that Activation of prefrontal cortex by tDCS reduces appetite for risk during ambiguous decision making. In this tDCS study the investigator uses one anode and one cathode electrode placed over the scalp to modulate a particular area of the central nervous system (CNS). The stimulation is administered via the neuroConn DC.Stimulator Serial number 0096. The DC-STIMULATOR is a micro-processor-controlled constant current source. The DC-STIMULATOR is a CE-certified medical device for conducting non-invasive transcranial direct current stimulation (tDCS) on people.Electrode positioning is determined according to the International EEG 10-20 System.
Interventions
DEVICEneuroConn_CE_DC-STIMULATOR
right frontal anodal stimulation
DEVICESHAM
no meaningful stimulation will be given
Sponsors
Loewenstein Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Ages 18-70 years. * Traumatic Brain injured patients who were diagnosed with executive function difficulties. * Patients who are able to cooperate and comprehend simple instructions. * Patients who can provide informed consent after both oral and written information was given and discussed.
Exclusion criteria
* Pregnancy. * Patients who sufferred a penetrating head trauma. * Patients who underwent a frontal craniotomy * Patients with a history of Psychiatric problems * In cases of Severe Porencephaly at stimulation site * Active Epilepsy or a history of seizure.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline MindStreams-NeuroTrax MINDSTREAMS-NEUROTRAX | day 1 (twice), day 15, day 21 | Computerized tests assess brain wellness across an array of cognitive domains including: memory, executive function, visual spatial perception, verbal function, attention, information processing speed, and motor skills. The psychometric properties of the tests exploit the advantages of computerized testing, providing precise accuracy and reaction time measurements. NeuroTrax offers an unbiased, standardized, accurate and inexpensive tool with a wide range of applicability. The specific tests that will be administered are Go-No Go Response Inhibition and Visual Spatial Processing |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline Behavior Rating Inventory of Executive Function- (Adult Version) BRIEF-A | day 1, day 21 | Measures an adult's views of him- or herself and captures important observer information for a comprehensive picture of the rated individual's executive functioning. |
| Change from baseline Wechsler Adult Intelligence Scale (WAIS-III ) | day 1 (twice), day 15, day 21 | 1\. The WAIS-III, a subsequent revision of the WAIS and the WAIS-R, was released in 1997. It provided scores for Verbal IQ (Intelligence quotient ), Performance IQ, and Full Scale IQ, along with four secondary indices (Verbal Comprehension, Working Memory, Perceptual Organization, and Processing Speed). |
Countries
Israel
Outcome results
None listed