Multimodal Intervention for Cachexia in Advanced Cancer Patients Undergoing Chemotherapy

Conditions

Cachexia, Neoplasms

Keywords

Combined modality treatment, Diet therapy, Exercise therapy, Ibuprofen, Dietary supplements

Brief summary

Cancer cachexia is a multi-factorial syndrome defined by an ongoing loss of skeletal muscle mass (with or without loss of fat mass) that cannot be fully reversed by conventional nutritional support and leads to progressive functional impairment. There is an urgency for improving management, but there is no consensus on the optimal treatment for cancer cachexia. Several single therapies for cancer cachexia have been examined in clinical trials, with disappointing overall results. As multiple factors are responsible for the development of cachexia, it has been argued that optimal cachexia interventions should target all components: multimodal therapy for a multimodal problem. The overall aim of this study is to early prevent the development of cachexia rather than treatment late in the disease trajectory. From a patient perspective a short term effect will be to improve physical and psychological function, to reduce symptom burden and to improve survival. In other words live a longer and better life during and after chemotherapy. Direct effects of the cachexia intervention are expected to be reduction of weight and muscle loss, and improved physical activity and quality of life.

Tora S. Solheim, Barry Laird, Trude R. Balstad, Guro B. Stene, Vickie E. Baracos et al. (20 authors)

Journal of Clinical Oncology2024-06-0515 citations

10.1200/jco.2024.42.17_suppl.lba12007

Power Comparisons and Clinical Meaning of Outcome Measures in Assessing Treatment Effect in Cancer Cachexia: Secondary Analysis From a Randomized Pilot Multimodal Intervention Trial

Trude R. Balstad, Cinzia Brunelli, Caroline Hild Hakvåg Pettersen, Svanhild A. Schønberg, Frank Skorpen et al. (11 authors)

Frontiers in Nutrition2021-01-1414 citations

10.3389/fnut.2020.602775

Cancer cachexia: rationale for the MENAC (Multimodal-Exercise, Nutrition and Anti-inflammatory medication for Cachexia) trial.

Solheim TS, Laird BJA, Balstad TR, Bye A, Stene G, Baracos V, Strasser F, Griffiths G, Maddocks M, Fallon M, Kaasa S, Fearon K.

2018-02-09130 citations

10.1136/bmjspcare-2017-001440

Unfavorable impact of cancer cachexia on activity of daily living and need for inpatient care in elderly patients with advanced non-small-cell lung cancer in Japan: a prospective longitudinal observational study.

Naito T, Okayama T, Aoyama T, Ohashi T, Masuda Y, Kimura M, Shiozaki H, Murakami H, Kenmotsu H, Taira T, Ono A, Wakuda K, Imai H, Oyakawa T, Ishii T, Omori S, Nakashima K, Endo M, Omae K, Mori K, Yamamoto N, Tanuma A, Takahashi T.

2017-11-2844 citations

10.1186/s12885-017-3795-2

Skeletal muscle depletion during chemotherapy has a large impact on physical function in elderly Japanese patients with advanced non-small-cell lung cancer.

Naito T, Okayama T, Aoyama T, Ohashi T, Masuda Y, Kimura M, Shiozaki H, Murakami H, Kenmotsu H, Taira T, Ono A, Wakuda K, Imai H, Oyakawa T, Ishii T, Omori S, Nakashima K, Endo M, Omae K, Mori K, Yamamoto N, Tanuma A, Takahashi T.

2017-08-2555 citations

10.1186/s12885-017-3562-4

Interventions

OTHERstandard care

Routine oncology and palliative care

DIETARY_SUPPLEMENTnutritional supplements and advice

n-3 PUFA enriched supplements, dietary advice

BEHAVIORALhome-based self-assisted exercise program

Strength and aerobic

DRUGIbuprofen

400mgx3

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* Diagnosis of lung cancer, pancreatic cancer or cholangiocarcinoma where the diagnosis is based on histological, radiological or multidisciplinary team (MDT) evaluation * non-small cell lung cancer (stage III or IV), pancreatic adenocarcinoma (stage III or IV), due to commence first or second line anticancer treatment (defined as chemotherapy, chemo-radiotherapy, targeted therapy or immunotherapy) * staging CT within 4 weeks of commencement of anti-cancer therapy (in patients where staging CT is out-with this period, further CT scanning will be undertaken. PETCT's are also appropriate) * completed all other baseline assessments within one week prior to first course of anti-cancer treatment * written informed consent * able to comply with trial interventions (in the opinion of referring clinician) e.g. willing and able to do light exercise and take oral nutritional supplements as well as no major contraindications against ibuprofen. * Karnofsky Performance Status \>70

Exclusion criteria

* Neuro-endocrine pancreatic cancer * Creatinine clearance \<30ml/min * Receiving parenteral nutrition or enteral nutrition via feeding tube * receiving neo-adjuvant anti-cancer therapy * BMI \>30 kg/m2 * Use of appetite stimulants or anabolic/anti-catabolic agents (such as megestrol acetate, progestational agents, marijuana growth hormone, dronabinol, or other anabolic agent) within 30 days prior to study baseline * Concomitant steroid (\>10mg/d prednisolone or equivalent) treatment for less than three months prior to inclusion (inhaled, optical or pulsed oral steroids (up to 10 days use) are permitted) * Concomitant long term (\>1 week) nonsteroidal anti-inflammatory drugs (NSAID) or aspirin treatment * pregnancy, breast-feeding or of child bearing potential (that is not postmenopausal or permanently sterilised) age and not using adequate contraception (oral, injected, implanted or hormonal methods of contraception, intrauterine device and barrier method) * Concomitant anti-coagulant treatment (e.g. warfarin or heparin)

Design outcomes

Primary

Measure	Time frame	Description
change in body weight	6 weeks	body weight (Kg)

Secondary

Measure	Time frame	Description
change in muscle mass	6 weeks	CT L3 cross sectional area
change in physical activity	6 weeks	ActivPAL step count

Countries

Canada, Germany, Norway, Switzerland, United Kingdom, United States

Outcome results

None listed