Relationship Between Pressure and Flow Velocity on Coronary Physiology

Status

Withdrawn

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02330861

Enrollment

Registered

2015-01-05

Start date

2014-12-31

Completion date

2017-02-28

Last updated

2018-08-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Stenosis

Keywords

Coronary Circulation

Brief summary

Subjects are patients who are planned to do percutaneous coronary intervention for coronary stenosis in the left circumflex artery without other stenosis in the left ascending artery and the right coronary artery, or a patient with normal coronary artery. Immediately after coronary angiography or percutaneous coronary intervention, the investigators will evaluate for coronary hemodynamics by distribution of wave intensity which is calcurated by coronary pressure and flow velocity with Combowire in each coronary segment. Also, they will assess coronary morphology by View It in each coronary segment.

Detailed description

Combowire (Volcano Therapeutics Inc., CA, USA) is a 0.014 inch pressure/Doppler sensor-tipped-guidewire which can measure coronary pressure and flow velocity. View It (Terumo Co., Japan) is a guide catheter with intravascular ultrasound which can measure coronary morphology such as vessel diamter.

Interventions

DEVICEcombowire and IVUS

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* A patient who are planned to do percutaneous coronary intervention for stenosis in the left circumflex artery without any lesions in other coronary arteries * Or a patient who is performed coronary angiography without significant stenosis lesion in 3-coronary vessel

Exclusion criteria

* A patient with coronary stenosis with LAD * Hemodialysis * Acute coronary syndrome * Congestive heart failure * A patient with shock vitals

Design outcomes

Primary

Measure	Time frame
Wave intensity	Immediately after coronary angiography or percutaneous coronary intervention

Secondary

Measure	Time frame
Coronary pressure	Immediately after coronary angiography or percutaneous coronary intervention
Flow velocity	Immediately after coronary angiography or percutaneous coronary intervention
Vessel diameter	Immediately after coronary angiography or percutaneous coronary intervention

Countries

Japan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026