Patients With Dental Extraction
Conditions
Brief summary
This is a randomized controlled trial with a split mouth design. Patients with an indication of lower dental extraction will be asked to join this research project at the Department of Oral and Maxillofacial Surgery at University of Damascus Dental School. Each patient whose case requires bilateral extraction, one side will serve as an experimental side, whereas the other side will serve as a control. Participants should have symmetric teeth that need extraction in the lower jaw. Hyaluronic acid will be injected following extraction in one of the two sides with random allocation. cone-beam computerized tomography (CBCT) images will be taken for each participant immediately post-extraction and at six months post-operatively.
Detailed description
I- Clinical examination variables: Buccolingual distance and distomesial distance will be measured for each participant at 2 assessment times: directly post-extraction and six months post-extraction. II- Radiographic examination variables: Linear measurements Vertical bone fill Bone mineral density
Interventions
DRUGHyaluronic Acid
This material is going to be injected into the extraction socket in order to promote bone healing.
Sponsors
Damascus University
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* 18-60 years old * Symmetric teeth requiring extraction in the lower jaw * Systematically healthy
Exclusion criteria
* Smokers * Pregnancy (for female participants) * Diabetic patients * Patients with metabolic problems
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in bone mineral density (BMD) | (BMD) will be measured two times in this study: directly at the day of extraction and six months post-extraction. | BMD is the amount of bone tissue in a certain volume of bone. This variable is going to be measured on CBCT images. |
| Vertical bone fill | This variable is going to be measured at 6 months post-extraction | 'Vertical bone fill' is the distance between the base of the extraction socket and cement-enamel junction directly after extraction and minus the distance between base of the extraction socket and cement-enamel junction six months post-extraction. This variable is going to be measured on CBCT images. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Buccolingual distance | at six months post-extraction | Buccolingual distance is the distance between buccal wall and lingual wall of the extraction socket. This variable is going to be measured clinically. |
| Mesiodistal distance | at six months post-extraction | Mesiodistal distance is the distance between mesial wall and distal wall of the extraction socket. This variable is going to be measured clinically. |
Countries
Syria
Outcome results
None listed