Coronary Artery Occlusive Dissease
Conditions
Brief summary
Surgical stress creates a state of insulin resistance which has been related to increased postoperative complications. Fasting before surgery induces a catabolic state that contributes to the development of insulin resistance. The aim of this study is to evaluate the effect of preoperative oral carbohydrates on postoperative insulin resistance in patients undergoing OPCAB (off-pump coronary artery bypass surgery). Sixty patients, aged 20 to 79 years, scheduled for OPCAB will be divided into carbohydrate (n=30) and control (n=30) groups. Randomly selected patients of the carbohydrate group are given 400ml of 12.8 g/100 ml carbohydrate beverage in the evening before surgery and in the morning of the operation day (3 hours before their scheduled operation). In contrast, patients in the control group consume no food or drink after midnight before their surgery. The primary endpoints are postoperative insulin resistance measured by short insulin tolerance test.
Interventions
DIETARY_SUPPLEMENTcarbohydrate beverage
400ml of 12.8 g/100 ml carbohydrate beverage
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 79 Years
Healthy volunteers
No
Inclusion criteria
* patients who are scheduled to undergo OPCAB
Exclusion criteria
* Subjects are ineligible if they have DM(Diabetes Mellitus), * Gastroesophageal reflux disease or gastric emptying disorder, * inflammatory bowel disease, * previous treatment for intra-abdominal cancer, * entered surgery more than 5 hours after ingestion of the morning carbohydrate beverage, * cognitive dysfunction, * disabling mental change disorder, * are unable to communicate or speak Korean
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative insulin resistance | within 1 hour after surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| preoperative discomfort | 24 hours | the preoperative discomfort measured by VAS (Visual Analog Scale) |
| perioperative hemodynamic effect | 24 hours | perioperative hemodynamic effect measured by amount of used vasopressors and minimum mixed venous oxygen saturation |
| postoperative complications | 24 hours | infection, Myocardiac infarction, Acute renal failure, re-operation, death, etc |
Countries
South Korea
Outcome results
None listed