Effects of Dexmedetomidine and Propofol on Pulmonary Mechanics

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02330120

Enrollment

Registered

2015-01-01

Start date

2011-01-31

Completion date

2015-08-31

Last updated

2015-12-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Abnormal Respiratory Airway Resistance

Keywords

peak airway pressure, airway resistance, sedation, intensive care

Brief summary

The aim of this study is to compare the effects of dexmedetomidine and propofol on pulmonary mechanics in intensive care patients.

Detailed description

The aim of this study is to compare the effects propofol and dexmedetomidine on pulmonary mechanics. Sixty patients mechanically ventilated in intensive care unit are included in this study. Patients are divided into two random groups, Group P (propofol) and Group D (dexmedetomidine). Propofol infusion 0.5-2 mg/kg/h is given to Group P patients and dexmedetomidine infusion 0.2-0.7 mcg/kg/h is given to Group D patients for sedation. Initial blood gas analysis, airway resistance (cmH2O/L/sec), positive end-expiratory pressure (PEEP, cmH20), frequency (breath/min), tidal volume (mL/min), minute volume (mL), peak airway pressure (cmH20), compliance (mL/cmH20), endtidal CO2 (mmHg), SvO2 (%) values are recorded. This parameters are evaluated with Drager Evita 4 ventilator and recorded on 5th,15th,30th,45th ve 60th minutes . Sedation is observed using Riker and Ramsey Sedation-Agitation Scale. Compliance of patients to mechanical ventilation is observed and recorded. The primary outcome measures are airway resistance and peak airway pressure. Secondary outcome measure is sedation score.

Interventions

DRUGpropofol

DRUGdexmedetomidine

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* The patients mechanically ventilated in intensive care unit

Exclusion criteria

* Patients with contraindications for using propofol and dexmedetomidine

Design outcomes

Primary

Measure	Time frame	Description
airway resistance	60 minutes	airway resistans measured by Evita 4 ventilator flow sensor
peak airway pressure values	60 minutes	peak airway pressure values provide the methods used to Evita 4 ventilator flow sensor

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026