Optic Neuropathy, Ischemic, Triamcinolone Acetonide
Conditions
Brief summary
NAION produces an ischemic insult in the optic nerve head presumably due to the hypoperfusion of the short ciliary arteries that supply it. Intravenous injection of glucocorticoid have proven to be effective in treatment of Nonarteritic Anterior Ischemic Optic Neuropathy,but have some side effects. the investigators believe that offering them Retrobulbar Triamcinolone Acetonide Injection that might halt the progression of the visual acuity and visual field loss if our hypothesis is correct, would greatly improve their chances of avoiding blindness.
Interventions
DRUGTriamcinolone Acetonide
DRUGplacebo
Sponsors
Second Military Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
Sudden mono ocular vision loss associated with optic disc edema and positive Marcus Gunn (\<30 days)
Exclusion criteria
Any eye disease except NAION(Nonarteritic Anterior Ischemic Optic Neuropathy) Neurologic defect Abnormal ESR, CRP, any history of retina or vitreal surgery Severe corneal opacity which makes retina examination impossible
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes of Best corrected visual acuity(BCVA) | baseline and 1month, 3month |
Secondary
| Measure | Time frame |
|---|---|
| Changes of Visual Field | baseline and 1month, 3month |
Contacts
Primary ContactDONGYAN PAN, Dr
Outcome results
None listed