Atopic Asthma
Conditions
Brief summary
The study will assess airway responses in mild atopic asthmatics undergoing repeat allergen challenge testing and will investigate whether ibuprofen changes the response.
Interventions
DRUGibuprofen
2x 200mg ibuprofen, single dose, blinded in 00 capsules
DRUGPlacebo
lactose filled 00 capsules to match appearance of ibuprofen intervention
Sponsors
University of Saskatchewan
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* diagnosis of mild asthma, currently well controlled requiring only a bronchodilator (e.g. salbutamol) as needed and infrequently * has allergies that trigger asthma * responds to methacholine challenge at 16mg/ml or less * has FEV1 \> 69.5% predicted
Exclusion criteria
* respiratory illness within 4 weeks * other medical condition assessed by the principal investigator that would put the participant at risk or influence the integrity of the data * pregnant or lactating females * hypersensitivity to ibuprofen
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Airway response to inhaled allergen | at time of allergen inhalation challenge and for 7 hours after | area under forced expiratory volume in one second versus time curve; 0-3hours (early response) and 3-7 hours (late response) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Airway response to inhaled methacholine | day before allergen inhalation challenge and 8 hours after allergen inhalation challenge | delta log methacholine PC20 (provocative concentration of methacholine causing a 20% decrease in the forced expiratory volume in one second) |
Countries
Canada
Outcome results
None listed