Genetic Analysis of Childhood Obesity

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02326480

Acronym

OSV

Enrollment

300

Registered

2014-12-29

Start date

2015-01-31

Completion date

2021-06-30

Last updated

2020-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Keywords

Childhood Obesity, Genetics

Brief summary

Identify news genetic causes of different type of obesity (syndromic, familial or isolated obesity) by highlighting new mutations or new implied genes

Interventions

OTHERIdentification of genetic causes of obesity

A blood test will be performed to the child and his/her parents with the aim of identifying genetic causes of obesity. Different analysis will be as follows: caryotypes, Raindance, whole exome, in order to find potential mutations or new genes associated to this condition

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

6 Months to 18 Years

Healthy volunteers

Yes

Inclusion criteria

* BMI \> curve of IOTF 30 (International Obesity Task Force) * Age: between 6 months old and 18 years old * Child presenting syndromic, isolated or familial obesity.

Exclusion criteria

* Common obesity * Impossibility for blood sampling * Impossibility to receive information * Participation refusal of one of the parents * Refusal to sign the informed consent * Neither Healthcare coverage nor insurance

Design outcomes

Primary

Measure	Time frame	Description
To identify the number of mutations or genes involved in genetic causes of Child obesity	first day of enrollement	Children with obesity and their parents will be recruited to establish genetic causes of obesity. This will allow perform genetic analysis using new approaches for the identification of involved mutations or new candidate genes

Secondary

Measure	Time frame	Description
To identify the number of mutations in the population	first day of enrollement	—
To identify the number of new mutations present in the children's DNA and absent from their parents' genomes	first day of enrollement	This approach will allow the identification of specific mutations that are present only in affected children but not in their parents
To determine number of phenotypes associated to the child obesity genotype	first day of enrollement	—

Countries

France

Contacts

Primary ContactAmélie Lansiaux, MD, PhD

lansiaux.amelie@ghicl.net

Backup ContactMélanie Hamez

hamez.melanie@ghicl.net

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026