The UHSM Cardiovascular Magnetic Resonance Study

Conditions

Cardiovascular Diseases

Brief summary

This study aims to investigate the diagnostic and prognostic utility of cardiovascular magnetic resonance (CMR) imaging in a large cohort of unselected patients who are undergoing CMR scanning for clinical indications (i.e. suspected/confirmed cardiovascular disease). CMR indices will be related to the presence and severity of cardiovascular disease and other markers of cardiovascular and health status.

Detailed description

Patients will undergo CMR scanning in the usual clinical manner. As part of the study, patients will undergo approximately 5 minutes of extra CMR scanning. Cardiovascular anatomical, structural and functional data will be recorded, including data pertaining to myocardial characteristics (e.g. extracellular volume, oedema, fibrosis, infarction, function, perfusion), pericardial disease; valvular disease; vascular structure and function. Blood sampling will be performed on the same day as CMR scanning for assessment of serum/plasma markers of cardiovascular disease and health status, and DNA analysis. Health questionnaires will be completed on the day of CMR scanning. Follow-up information regarding health status, demographics and concurrent medical conditions and treatments will be obtained over a 10 year period following CMR scanning.

Brown PF, Di Marco A, Tsoumani Z, Reid A, Bradley J, Nucifora G, Anguera I, Miller C, Schmitt M.

2023-12-08

10.1007/s10554-023-03024-4

Growth differentiation factor-15 in patients with or at risk of heart failure but before first hospitalisation

Joshua Bradley, Erik B. Schelbert, Laura Bonnett, Gavin A. Lewis, Jakub Lagan et al. (13 authors)

Heart2023-08-1111 citations

10.1136/heartjnl-2023-322857

Extracellular volume fraction improves risk-stratification for ventricular arrhythmias and sudden death in non-ischaemic cardiomyopathy

Andrea Di Marco, Pamela Frances Brown, Joshua Bradley, Gaetano Nucifora, Ignasi Anguera et al. (7 authors)

European Heart Journal - Cardiovascular Imaging2022-07-2529 citations

10.1093/ehjci/jeac142

Risk stratification and prognostic value of CMR in DCM; parametric mapping and GLS- value beyond EF and LGE?

Pamela Frances Brown, Anthony Dimarco, Joshua Bradley, Gaetano Nucifora, Chris Miller et al. (6 authors)

European Heart Journal - Cardiovascular Imaging2021-01-01

10.1093/ehjci/jeaa356.315

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

Any adult patient undergoing clinically indicated CMR scanning at the UHSM CMR Unit.

Exclusion criteria

Age \< 18 years, imprisonment, inability to provide informed consent.

Design outcomes

Primary

Measure	Time frame
All cause mortality	10 years with planned interim analyses

Secondary

Measure	Time frame
Cardiovascular death	10 years with planned interim analyses
Hospitalisation for heart failure	10 years with planned interim analyses
Development of cardiovascular disease	10 years with planned interim analyses
Development of complications of cardiovascular disease	10 years with planned interim analyses

Countries

United Kingdom

Outcome results