Bone Diseases, Metabolic
Conditions
Keywords
Osteoporosis, Dried plum, functional food
Brief summary
The objective of the investigators current study was to examine whether 50 g dried plum would be as effective as 100 g dried plum in reversing bone loss in osteopenic older postmenopausal women.
Detailed description
Forty-five randomly assigned into one of three treatment groups: 1) 50g dried plum; 2) 100g dried plum; and 3) control (0g dried plum). All groups received 500mg calcium and 400 IU vitamin D as a daily supplement. Blood samples were collected at baseline, 3 and 6 months to assess biomarkers of bone turnover. Physical activity recall and 3-day food records were obtained at baseline, 3 and 6 months to examine physical activity and dietary confounders as potential covariates
Interventions
OTHERDried Plum
Three doses of dried plum (0 g, 50 g and 100g) were used as intervention.
Sponsors
Florida State University
San Diego State University
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
65 Years to 79 Years
Healthy volunteers
Yes
Inclusion criteria
* BMD t-score of L1-L4 between -1 to -2.5 standard deviation of the mean * Age 65 to 79
Exclusion criteria
* BMD t-score at any site fell below 2.5 standard deviation of the mean * Subjects treated with calcitonin, bisphosphonates, raloxifene and/or anabolic agents such as parathyroid hormone and growth hormone, or steroids within three months before the start of the study * Metabolic bone disease, renal disease, cancer, CVD, diabetes mellitus, respiratory disease, gastrointestinal disease, liver disease or other chronic diseases, heavy smoking (more than twenty cigarettes/day) and current use of any prescription medications known to alter bone and calcium metabolism * Regularly consumed dried plum or prune juice were not included in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bone Mineral Density | 6 months |
Secondary
| Measure | Time frame |
|---|---|
| Changes from baseline in bone specific alkaline phosphatase at 3 months and 6 months | baseline, 3 months and 6 months |
Outcome results
None listed