Effect of Specific Diet and Physical Activity on Weight and/or Fat Loss

Conditions

Obesity

Keywords

overweight and obesity, adipose tissue, weight loss program, low-calorie diet, circuit-based exercise, metabolic cardiovascular syndrome

Brief summary

The main purpose of this study is to assess metabolic effects (decreased amount of body fat content, insulin sensitivity and lipid profile improvement) of weight loss intervention based on specific life style counseling (low calorie metabolic stairs diet and circuit-based exercise in a comparison to conventional diet and exercise. The main hypothesis is that more significant beneficial metabolic effects will have specific life style counseling effect than conventional diet and exercise. The main purpose of this study is to assess above mentioned metabolic changes before and after 6-8 weeks of weight loss intervention. The investigators will also study the following: 1. The impact of life style counseling induced weight and/or fat loss on physical fitness 2. The impact of life style counseling induced weight and/or fat loss on metabolic parameters (e.g. insulin sensitivity, lipid profile, ect.)

Detailed description

I

Libuša Nechalová, Viktor Bielik, Ivan Hric, Miriam Babicová, Eva Baranovičová et al. (8 authors)

BMC Sports Science Medicine and Rehabilitation2024-12-059 citations

10.1186/s13102-024-01029-7

Gut Microbiota and Serum Metabolites in Individuals with Class III Obesity Without Type 2 Diabetes Mellitus: Pilot Analysis

Libuša Kubáňová, Viktor Bielik, Ivan Hric, Simona Ugrayová, Katarína Šoltýs et al. (10 authors)

Metabolic Syndrome and Related Disorders2023-04-212 citations

10.1089/met.2022.0071

Effect of weight loss on cardiometabolic risk factors in obese patients

Adela Penesová, Jana Babjaková, Andrea Havranová, Richard Imrich, Miroslav Vlček

European Journal of Public Health2020-09-01

10.1093/eurpub/ckaa166.192

Effect of 8-weeks intensive lifestyle intervention on LDL and HDL subfractions.

Bajer B, Rádiková Ž, Havranová A, Žitňanová I, Vlček M, Imrich R, Sabaka P, Bendžala M, Penesová A.

2019-11-0114 citations

10.1016/j.orcp.2019.10.010

Improved Insulin Sensitivity and Irisin after a Dietary Weight-Lowering Program in Obese, Otherwise Healthy Subjects

Adela Penesová, Žofia Rádiková, Boris Bajer, Miroslav Vlček

Diabetes2018-06-22

10.2337/db18-2082-p

Interventions

BEHAVIORALLifestyle Counseling

In both arms life style counseling: Low calorie diet- 30% reduction of weight maintenance calories (TDEE); and recommended moderate exercise 3 times per week 45 minutes.

Study design

Allocation

RANDOMIZED

Intervention model

FACTORIAL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy Volunteers * BMI≥25 kg/m2

Exclusion criteria

* Thyroid disease * Chronic diseases(rheumatic,liver, kidney, pulmonary, etc. diseases) have current signs or symptoms of severe, progressive or uncontrolled renal, hepatic, hematologic, gastrointestinal, endocrine, pulmonary, cardiac, neurologic, or cerebral disease, or diabetes; * chronic infections * show evidence of malignancy * be women who are pregnant, nursing * medical treatment except allergy medicines * tobacco, alcohol or drug addiction

Design outcomes

Primary

Measure	Time frame	Description
A Body weight change after specific weight loss intervention	8 weeks	To assess the body composition changes (fat-free mass and fat mass (in kg)).

Secondary

Measure	Time frame	Description
Metabolic parameters	8 weeks	* Insulin sensitivity * Total, HDL, LDL, small dense-LDL cholesterol levels

Countries

Slovakia

Outcome results

None listed