Comparison of CTI Ablation Prior to or After LA Ablation for AF

Randomized, Single-blind, Comparative Trial of Two AF Ablation Strategies (CTI Ablation Prior to LA Ablation Versus CTI After LA Ablation) to Eliminate Persistent AF

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02325778

Enrollment

132

Registered

2014-12-25

Start date

2010-01-31

Completion date

Unknown

Last updated

2016-08-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial Fibrillation

Brief summary

This study is designed to determine if CTI prior to CPVA/PVI/Linear Lesions/Fractionation results in reduced left atrial ablation lesion sets prior to restoration of sinus rhythm in patients with long standing persistent atrial fibrillation in the absence of antiarrhythmic drug therapy compared to CTI after CPVA/PVI/Linear Lesions/Fractionation.

Interventions

PROCEDURECTI ablation Timing

The timing of when the CTI ablation is performed. There are no other relevant interventions used in the procedure.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* continuous/persistent atrial fibrillation

Exclusion criteria

* age\<18 * congenital heart disease * pacemaker or ICD implant * previous ablation

Design outcomes

Primary

Measure	Time frame
Number of Ablation Lines Required to Organize Atrial Fibrillation to an Atrial Tachycardia or Sinus Rhythm	Acute (intra procedure)

Secondary

Measure	Time frame	Description
Early recurrence of atrial arrhythmias	3 months	Atrial Fibrillation or Atrial Tachycardia lasting longer than 30 seconds

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026