Congential Cardiac Surgery
Conditions
Keywords
congential cardiac surgery, nuclearsome, systemic inflammation response syndrome
Brief summary
In this study，the investigators want to determine the corelation between circulating nuclearsome and the development of SIRS occured after congenital cardiac surgery, including the serverity of organ damage and inflamation.
Detailed description
Blood was collected from study participants at 6 time points; 1) post-anesthesia induction, 2) post-op hour 0, 3) post-op hour 4, 4) post-op hour 24, 5) post-op hour 48, and 6) post-op hour 72. At each of the 6 time points blood was analyzed for levels of the following:histone,blood routine test , c-reaction protein, procalcitonin, N-terminal pro-brain natriuretic,the hepatorenal function，cardiac function and pulmonary function
Interventions
None listed
Sponsors
Shanghai Children's Medical Center
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Months to 3 Years
Healthy volunteers
No
Inclusion criteria
* children with congenial heart disease
Exclusion criteria
* Less than 2.5kg * Prematurity less than 37 weeks estimated gestational age * Renal failure as described by the pediatric RIFLE criteria
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the perioperation change of histone level | preoperation to 72 hours after congential cardiac surgery |
Secondary
| Measure | Time frame |
|---|---|
| the perioperation change of c-reaction protein level | preoperation to 72 hours after congential cardiac surgery |
| the perioperation change of cardiac function | preoperation to 72 hours after congential cardiac surgery |
| the perioperation change of blood routine test | preoperation to 72 hours after congential cardiac surgery |
Countries
China
Outcome results
None listed