RRI Compared With NephroCheckTM to Predict Acute Renal Failure After Cardiac Surgery.

Renal Resistive Index Compared With NephroCheckTM to Predict Postoperative Acute Renal Failure in Patients Undergoing Cardiac Surgery.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02325726

Enrollment

Registered

2014-12-25

Start date

2014-09-30

Completion date

2014-11-30

Last updated

2015-11-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Surgery, Extracorporeal Circulation, Nephrocheck, Renal Failure

Keywords

Cardiac surgery, Extracorporeal circulation, Renal failure

Brief summary

Postoperative acute renal failure is a frequent complication after cardiac surgery. The current practice cannot predict Acute Kidney Injuries (AKI) early enough to reduce a significant kidney assault and prevent an organic dysfunction leading to cortical tubular necrosis. Several recent studies in cardiac surgery have shown that, both sonographic criteria, such as the Renal Resistive Index (IRR) and urinary biomarkers can predict AKI promptly. These urinary biomarkers are the 'tissue inhibitor of metalloproteinases' (TIMP-2) and the 'insulin-like growth factor binding protein' (IGFBP7). These two proteins are sought noninvasively, directly in the urine, within the same test called 'NephroCheckTM'. These markers, ultrasonographic and biologic, have the advantage of being easy to perform, accessible and seem to have both high sensitivity and specificity to predict AKI promptly after cardiac surgery. Thus, the IRR and the NephroCheckTM test could become essential tests to guide clinicians in determining rapidly whether a patient will develop AKI. However, so far, no study has compared these markers yet. Therefore, the aim of this prospective observational study will be to compare the effectiveness of the IRR with the NephroCheckTM to predict AKI promptly after cardiac surgery. The secondary outcome will be to determine the threshold of these markers from which patients will be likely to develop AKI

Interventions

PROCEDURERenal Resistive Index compared with NephroCheckTM

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Elective patients * Patients scheduled to receive an extracorporeal circulation * Patients aged 60 and older * Patients at risk of postoperative acute kidney injury presenting at least two of the following risk factors: * Age \> 60 years. * Arteritis defined as severe lower limb arteriopathy or carotid stenosis \> 50% * Diabetes * Valvular or combined surgery * Preoperative intra-aortic balloon pump.

Exclusion criteria

* Unable to provide informed consent * Comatose patients * Patients with dementia * Patient who underwent a previous sternotomy * Chronic renal failure (sCr clearance \< 30 ml.min-1) * Renal artery stenosis * Endocarditis * Emergent surgery * Nephrotoxic treatment * Non-sinus cardiac rhythm

Design outcomes

Primary

Measure	Time frame	Description
Renal Resistive Index compared with NephroCheckTM	Day 0 (inclusion) / after cardiac surgery	Compare the effectiveness of the IRR with the NephroCheckTM to predict AKI after cardiac surgery. AKI will be defined according to the RIFLE criteria.

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026