Investigate the Role of microRNA in Chronic Rhinosinusitis From DC-Th Axis

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02325596

Acronym

ITROMICRFDTA

Enrollment

Registered

2014-12-25

Start date

2014-07-31

Completion date

2016-12-31

Last updated

2014-12-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rhinosinusitis

Keywords

Chronic rhinosinusitis, microRNA, dendritic cell, helper T cell

Brief summary

This study aimed to evaluate the upstream events of Th17/Treg imbalance in CRS and their immune regulatory factors. Then the investigators aimed to explore the regulatory role of miRNA on DC-Th axis and its dysfunction in the pathogenesis of CRS, in order to determine the miRNA expression profile in CRS and clarify the role of miRNA in the pathogenesis of CRS by regulating the DC-Th axis.

Detailed description

Chronic rhinosinusitis (CRS), commonly encountered in the ﬁeld of clinical otorhinolaryngology, is still a challenging proposition for doctors because of its high incidence and the unsatisfactory treatment outcomes. Nowadays, studies on the pathogenesis of NP are still attached great importance by researchers from each country. NP has become a global health problem with a considerable socioeconomic burden. Recently, research showed that the impaired balance of Th17/Treg was the significant basis of NP. Nevertheless, the pathogenesis of Th17/Treg imbalance was unclear. In this study, DC-Th axis was designed as the main line, and the regulation of miRNA on DC was designed as the entry point. This study aimed to evaluate the upstream events of Th17/Treg imbalance in CRS and their immune regulatory factors. Then the investigators aimed to explore the regulatory role of miRNA on DC-Th axis and its dysfunction in the pathogenesis of CRS, in order to determine the miRNA expression profile in CRS and clarify the role of miRNA in the pathogenesis of CRS by regulating the DC-Th axis. This study will play an important role in clarifying the pathogenesis of CRS eventually and will fill the blanks of the research between miRNA and CRS in the investigators'country. This study is with important clinical value for establishing control strategies for CRS.

Interventions

GENETICmiRNA mimics or inhibitors

DCs are transfected by the miRNA mimics or inhibitors after they are separated from peripheral blood mononuclear cells in CRS patients

Study design

Observational model

CASE_CONTROL

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

1. CRS diagnosis is accord with diagnostic criteria of The European nasal sinusitis, nasal polyps guidelines (EPOS 2012) . 2. Selected subjects are stopped using systemic or topical corticosteroids in one month before experiment. 3. All the patients have sinus CT and nasal endoscopy and allergen Skin Prick Test in preoperative. 4. Aged from 18 to 75 years old. 5. Woman or man.

Exclusion criteria

1. Choanal polyp, fungal nasal sinusitis, cystic fibrosis. 2. Acute upper respiratory tract infection and other diseases associated with the body.

Design outcomes

Primary

Measure	Time frame
Abnormal microRNA in the Chronic Rhinosinusitis are found by gene chip and qPCR.	6 to 24 months post procedure

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026