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Evaluation of Three Types of Injection for the Treatment of Lateral Epicondylalgia

Leukocyte and Platelet Rich Plasma Versus Type A Botulinum Toxin Versus Glucocorticoids for the Treatment of Lateral Epicondylalgia: a Randomized, Multicenter, Double-blind, Therapeutic Trial With Three Parallel Arms

Status
Terminated
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02325063
Acronym
LET
Enrollment
13
Registered
2014-12-24
Start date
2015-12-17
Completion date
2017-05-02
Last updated
2025-12-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epicondylitis, Lateral Humeral, Tennis Elbow

Brief summary

The primary objective of this study is to compare the evolution of pain profiles among patients suffering from lateral epicondyalgia (tennis elbow) following three types of treatment: PRP-L injection versus type A botulinum toxin injection versus corticoid injection.

Detailed description

The secondary objectives are to compare the following among the three groups: A- The global efficacy of each treatment defined by a minimum reduction of 25% in average pain over the last 24 hours between 0 and 6 months. B- The evolution of average pain over the last 24 hours between 0 and each different time frame (3 weeks, 6 weeks, 3 months and 6 months). C- The evolution of maximum pain scores using nocturnal post-effort (Jamar grip test) visual analog scales (VAS) between day 0, 3 weeks, 6 weeks, 3 months and 6 months. D- The perception of change on the Patient's Global Impression of Change score (PGIC) at 3 and 6 months E- The evolution of PRTEE scores at 0, 3 and 6 months F- Adverse events at 3 weeks, 6 weeks, 3 months and 6 months. G - Quality of life and utility via the SF-12 at 3 and 6 months. H- The consumption of analgesics.

Interventions

DRUGPRP-L Injection

Patients will be treated with an injection of leukocyte and platelet rich plasma.

Patients will be treated with an injection of Type A Botulinum toxin.

DRUGCorticoid injection

Patients will be treated with an injection of Corticoids.

Sponsors

Centre Hospitalier Universitaire de Nīmes
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

General inclusion criteria: * The patient must have given free and informed consent and signed the consent * The patient must be affiliated or beneficiary to a health insurance plan * The patient is available for 6 months of follow-up * Woman of childbearing age using contraception Inclusion criteria for the target population: the patient has a side epicondylalgia objectified by: * Clinical criteria: symptoms lasting for more than 6 weeks and less than 12 months. The list of symptoms to be present are: pain on palpation of the lateral epicondyle, pain in the lateral epicondyle during blocked contraction * Therapeutic: less than two injections of corticosteroids performed, and the last such injection was performed at least 3 months before inclusion General non-inclusion criteria: * The patient is participating in another study * The patient is exclusion period determined by a previous study * The patient is under judicial protection * The patient is under guardianship or curatorship * The patient refuses to sign the consent * Woman of childbearing age not using contraception * Impossible to correction inform the patient about the study Non-inclusion criteria for investigational and auxiliary medicinal products: * The patient has at least one of the contra-indications listed in the SPC for Xeomin and ALTIM: * Hypersensitivity to Botulinum neurotoxin type A or Cortivazol * Hypersensitivity to any of the excipients used in the composition of XEOMIN (Human albumin, sucrose) and / or ALTIM (Benzyl alcohol, carmellose sodium, sodium chloride, cetylpyridinium chloride, polysorbate 80) * Generalized disorders of muscle activity (eg myasthenia gravis, Lambert-Eaton syndrome). * Severe coagulation disorders, anticoagulation in progress (ticlopidine, clopidogrel, other antiplatelet or antithrombotic agents) * Presence of a local or general infection, suspected infection, infection at the proposed injection site. Non-inclusion criteria for the medical device used for the PRP samples (SmartPReP2 sampling system): * Clinical or laboratory evidence for sepsis * Taking aspirin or other drugs altering platelet function in the previous 3 days * Patient with the platelet dysfunction disorders Non-inclusion criteria for interfering diseases or conditions: * The patient is pregnant, parturient or she is breastfeeding * The patient has an allergy to botulinum toxin type A and / or glucocorticoids * The patient has medial epicondylalgia * The patient has a history of elbow surgery * The patient has any of the following conditions: immunodeficiency, rheumatic disease, hepatitis, diabetes, another disease of the ipsilateral limb, neurological disorder (radiculopathy, compression of the radial nerve), any myopathy (all etiologies) * The patient received treatment with corticosteroids in the last 3 months * The patient is being treated with long-term anti-platelet medication

Design outcomes

Primary

MeasureTime frameDescription
Visual analog scale (VAS) for pain over the last 24 hours6 months versus Baseline (day 0)score varying from 0 to 10

Secondary

MeasureTime frameDescription
Visual analog scale for pain over the last 24 hoursBaseline (day 0)score varying from 0 to 10

Other

MeasureTime frameDescription
PRTEE ScoreBaseline (day 0)The Patient-Rated Tennis Elbow Evaluation
Patient Global Impression of Change3 monthsscore varying from 1 to 7
Global efficacy6 monthsDefined as the proportion of patients for whom a decrease in visual analog scales for pain over the last 24 hours of at least 25% has been observed over the past 6 months.
The SF 12 questionnaire3 months
The consumption of analgesics.Baseline (day 0)
Number of patients with adverse effectsBaseline (day 0)
VAS for pain after a Jamar grip testBaseline (day 0)score varying from 0 to 10

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026