Intervention Affecting Autonomic Nervous System
Conditions
Keywords
autonomic nervous system, heart rate variability, laparoscopic surgery, general anesthesia, photoplethysmography
Brief summary
The autonomic nervous system state (ANSS) and the autonomic nervous system state index (ANSSi) - two indices derived from the pulse photo-plethysmography analysis - have been recently advocated as a measure of sympathetic activity in the anesthetized patients, but their validity has not been yet demonstrated. We will conduct a study aiming to assess if ANSS and ANSSi reflect autonomic nervous system modulation on cardiovascular system in healthy humans under general anaesthesia.
Interventions
PROCEDUREautonomic nervous system analysis
electrocardiographic and pulse-photoplethysmographic waves of patients under general anesthesia for laparoscopic cholecystectomy will be recorded on a laptop pc for offline analysis of autonomic nervous system modulation a three main time point: 1) at baseline, before general anesthesia induction, 2) five min after tracheal tube placement, 3) five min after pneumoperitoneum insufflation.
Sponsors
ASST Fatebenefratelli Sacco
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* aged between 18 and 50 years * American Society of Anaesthesiologists status I and II
Exclusion criteria
* hypertension requiring pharmacological treatment or chronic cardiovascular disease * arrhythmic cardiac disease (atrial fibrillation, atrial flutter, ectopic beats \>5% of normal sinus beats) * history of alcohol or drug abuse * obesity (BMI\>30) * diabetes or other endocrine pathology (thyroidal or adrenal) * peripheral neuropathy or any kind of chronic neurological disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| autonomic nervous system activity during laparoscopic cholecystectomy (measured by pulse-photoplethysmography and heart rate variability analysis) | 120 min | assessment of autonomic nervous system activity measured by pulse-photoplethysmography and heart rate variability analysis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| agreement of photoplethysmography and heart rate variability | 120 min | assessment of agreement between pulse-photoplethysmography and heart rate variability as a measure of autonomic nervous system activity |
Countries
Italy
Outcome results
None listed