Pilot Study: Intraoperative Clonidine and Postoperative Behaviour

Randomised Controlled Pilot Study: Does Intraoperative Clonidine Reduce the Incidence of Post-hospitalisation Negative Behaviour Changes in Children Who Are Distressed During the Induction of General Anaesthesia?

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02324413

Enrollment

Registered

2014-12-24

Start date

2013-10-31

Completion date

2014-03-31

Last updated

2014-12-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Negative Behaviour Change

Brief summary

Children who are upset during induction of general anaesthesia are frequently distressed postoperatively and are more likely to demonstrate negative behaviour changes. This pilot study is a randomised controlled study of clonidine vs placebo during anaesthesia to identify whether postoperative behavioural disturbance may be minimised.

Interventions

DRUGClonidine

Comparison between placebo and 2 different concentrations of clonidine

DRUGPlacebo

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

2 Years to 10 Years

Healthy volunteers

Inclusion criteria

* age 2 to 10 years inclusive * healthy (ASA 1 or 2)

Exclusion criteria

* inability of parents to understand english

Design outcomes

Primary

Measure	Time frame
Number of negative changes on the post-hospitalization behavior questionnaire	24 hours and 7 days

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026