Salivary and Serum Levels of Chemerin and MMP-9 in Oral Premalignant and Malignant Lesions

Salivary and Serum Levels of Chemerin and MMP-9 in Oral Precancer and Oral Squamous Cell Carcinoma.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02323672

Enrollment

Registered

2014-12-23

Start date

2014-02-28

Completion date

2014-10-31

Last updated

2017-02-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral Cancer, Precancerous Conditions

Brief summary

45 individuals were subdivided into 3 groups, 15 patients with oral premalignant lesions, 15 patients with oral malignant lesions and 15 control individuals. Levels of chemerin and MMP-9 were evaluated in serum and saliva of these subjects utilizing the ELISA technique.

Detailed description

45 individuals were subdivided into 3 groups, 15 patients suffering from oral premalignant lesions, 15 patients suffering from oral malignant lesions and 15 individuals having age, gender and periodontal status matched with both patients groups acting as a control group. Serum and whole unstimulated saliva samples were collected from all the included groups in order to determine chemerin and MMP-9 in serum and saliva utilizing the ELISA technique.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

40 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* patients with oral premalignant lesions. * patients with oral malignant lesions.

Exclusion criteria

* any systemic disease other than oral premalignant or malignant lesions. smokers. pregnant females. periodontal diseases.

Design outcomes

Primary

Measure	Time frame
salivary levels of chemerin in patients with oral premalignant and malignant lesions.	1 day

Secondary

Measure	Time frame
serum levels of chemerin in patients with oral premalignant and malignant lesions.	1 day
serum levels of MMP-9 in patients with oral premalignant and malignant lesions.	morning visit
salivary levels of MMP-9 in patients with oral premalignant and malignant lesions.	1 day

Outcome results