Colorectal Cancer, Hypoxia, Sleep Apnea Syndromes
Conditions
Brief summary
212 patients with colorectal cancer will be investigated before surgery and 100 of them after surgery. 597 individuals from a previous population based study will serve as controls to the prevalence of sleep apnea in the general population. Investigations will include polysomonographic sleep apnea recordings during one night, lung function measurements, blood gas samples and questionnaires. Controls: Men and women from two population-based cohort studies
Detailed description
Inclusion: 212 patients with colorectal cancer will be investigated before surgery and 100 of them will also be investigated in the same manner after surgery. Due to drop-outs we calculate a need of inviting at least 250 patients. Controls: 597 individuals from a previous population based study will serve as controls to the prevalence of sleep apnea in the general population. Exclusion: Dementia, CPAP treated sleep apnea investigations: Patients are investigated with lung function, blood-gas samples, questionnaires, overnight polysomnographic sleep apnea recordings including oro-nasal airflow, thoraco-abdominal respiration belts, chin-EMG, EOG, EEG, ECG (V5) and body position. Controls: Men and women from two population-based cohort studies the Sleep and health in women and the Men in Uppsala: A Study of Sleep, Apnea and Cardiometabolic Health and older men and women from a local senior organization. Outcomes: Prevalence of sleep apnea and hypoxia, sleep quality, and lung function, blood gas, STOP-BANG, Epworth sleepiness scale, Mallampati score, symptoms of sleep apnea, surgical complications, mortality, cancer severity.
Interventions
PROCEDURESurgery for colorectal cancer
Includes open and minimally invasive surgery for colon- and rectal cancer
OTHERNo Interventions
This is a control group from the population. They are not scheduled for surgery
Sponsors
Karl A Franklin
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Patients scheduled for surgery of colorectal cancer
Exclusion criteria
* Dementia, CPAP treatment for obstructive sleep apnea
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of sleep apnea | 1 week | Apnea-hypopnea index |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| hypoxia, hypercapnia | 1 week | blood-gas measurements |
| lung function | 1 week | FVC, FEV1 |
| subjective sleepiness | 1 week | Eworth sleepiness scale |
| Mortality | Until death | From the swedish death register |
| Side effects of surgery | 30 days | From local register |
| Sleep quality | 1 week | total sleep time, sleep efficiency, time in different sleep stages |
| nocturnal hypoxia | 1 week | Pulsoximetry during polysomnography |
| Mallampati score | 1 day | Inspection of mouth |
| STOP-Bang | 1 week | Risk factor stratification |
| Symptoms of sleep apnea | 1 month | snoring, daytime sleepiness, witnessed sleep apneas |
| Sex differences | 1 month | Effect of sex on outcome |
| Severity of cancer | 30 days | Morphologic analysis of cancer type |
Countries
Sweden
Outcome results
None listed