Deafness
Conditions
Keywords
cochlear implant, deafness, audiometry, speech perception, severe to profound deafness restored with cochlear implantation
Brief summary
This study aims at investigating new automatic fitting techniques for cochlear implant patients based on objective measures. For this reason, the evolution of these neurophysiological measures, expressing the encoding of pure tones and speech, will be characterized in cochlear implanted patients as a function of post-implantation time and will be compared to those of normal hearing subjects. Moreover, the effect of auditory training with new tools based on serious games will be assessed.
Interventions
OTHERAuditory steady-state response ASSR
comparison of ASSR amplitudes in response to amplitude-modulated sounds delivered at different intensities
OTHERSpeech-ABR
OTHERAcoustic Change Complex ACC
comparison of ACC complex in response to changes within speech stimulation
OTHERP1-N1-P2 complex and Mismatch Negativity MMN
comparison of amplitudes and latencies of P1-N1-P2 complex and MMN generated in response to the detection of changes in a series of auditory stimulation
Sponsors
Hospices Civils de Lyon
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
1 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* native French speaker * no medical treatment for behavior or neurological disorders * normal or corrected vision * right-handed * normal ORL examination * valid affiliation to social security * absence of participation to another study For the cochlear implanted patients: * aged from 1 to 70 * bilateral severe to profound deafness * cochlear implant * congenital deafness, pre or post lingual For the normal-hearing subjects: * Aged from 18 to 70 * Normal tonal audiometry
Exclusion criteria
* No signed consent * Treatment for depression, epilepsy, Parkinson's or Alzheimer's disease * Physical health deficiency * Mental retardation * Neurological or psychiatric disease incompatible with the testing procedure * Schooling in a foreign language * Foreign language spoken at home with both parents * Invalid social security * For the normal hearing subjects, no known hearing deficits
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Amplitude of auditory steady state responses ASSR | one year at least after CI activation | — |
| Spectro-temporal analysis of speech-ABR | one year at least after CI activation | — |
| Acoustic Change Complex ACC | one year at least after CI activation | Amplitudes and latencies of ACC |
| amplitudes and latencies of P1/N1/P2 complex and Mismatch Negativity MMN | one year at least after CI activation | — |
| Evolution of amplitude of auditory steady state responses ASSR | 1 month, 3 months, 6 months, 9 months and 12 months after CI activation | Evolution of ASSR amplitudes as a function of time during the first year of CI activation in newly implanted patients |
| Evolution of spectro-temporal analysis of speech-ABR | 1 month, 3 months, 6 months, 9 months and 12 months after CI activation | Evolution of spectro-temporal analysis of speech-ABR as a function of time during the first year of CI activation in newly implanted patients |
Countries
France
Outcome results
None listed