Anomalous Self-Experience in First Episode Psychosis - A Six-Year Follow-Up Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02321943

Enrollment

Registered

2014-12-22

Start date

2015-02-28

Completion date

2016-12-31

Last updated

2017-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Affective Disorders, Psychotic, Schizophrenia and Disorders With Psychotic Features, Self Concept

Brief summary

The objective of this study is to explore the longitudinal course of self-disturbances (SD) in schizophrenia. The main aim of the study is to investigate, in a 6-7-year follow-up of a representative sample of patients with first-episode schizophrenia, bipolar disorder and other psychoses. The overall aim is to expand our knowledge about the role of SDs in psychotic disorders. Increased knowledge here will aid diagnosis and treatment. The current study is a seven year follow-up of this representative cohort, with baseline measures of SDs and a comprehensive clinical and neurocognitive assessment battery.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Patients who participated and completed base-line part of the study, * Patients with concurrent substance use disorder are included, but have to demonstrate at least one month without substance use, or clear signs that the psychotic disorder had started before the onset of significant substance use.

Exclusion criteria

* Patients with brain injury, * Patients with on going substance use, * Unable to provide informed consent statement. * Not able to be interviewed.

Design outcomes

Primary

Measure	Time frame
Change From Baseline in EASE (Examination of Anomalous Self-Experience)Total Score and Subscales of EASE	6 year

Secondary

Measure	Time frame
Change from Baseline for Structured Clinical Interview for the DSM ( SCID-I)(DSM-IV)	6 year

Other

Measure	Time frame	Description
Change from Baseline for Alcohol and Drug Use Disorder Identification Test (AUDIT and DUDIT)	6 year	—
Change From Baseline in Positive and negative syndrome	6 year	Positive and Negative Syndrome Scale (PANSS) Total Score and Subscales of PANSS
Change from Baseline for Global Assessment of Functioning - split Version(GAF)	6 year	—
Change from Baseline for neurocognitive tests battery	6 year	—
Change From Baseline in Calgary Depression Scale Score for Schizophrenia (CDSS)	6 year	—

Countries

Norway

Outcome results