Heart Failure, Recent Onset Atrial Fibrillation
Conditions
Brief summary
Prospective randomized (rhythm control or rate control in heart failure patients with new onset atrial fibrillation) Objective of study 1. To analyze long term outcome of patients with heart failure with new onset atrial fibrillation according to the rhythm control 2. To analyze remodeling of atrium and ventricle by the new onset AF in heart failure patients 3. To analyze the change of LV function and functional capacity according to the rhythm in patients with HF and new onset AF
Interventions
PROCEDURESinus Rhythm control
PROCEDUREPulse Rate control
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Patients with Heart failure and Atrial fibrillation within 1year (20\ 80 years old) 2. LA diameter \< 5mm 3. LVEF 20\ 49% 4. patients possible to anticoagulation and anti arrhythmic drug 5. Expected survival \>1yr
Exclusion criteria
1. Impossible to anticoagulation or anti arrhythmic drug 2. valvular atrial fibrillation ( Mitral valve stenosis, Mitral valve plasty, valve replacement) 3. LV ejection fraction \< 20% 4. Structural cardiac disease 5. Catheter ablation history for AF, maze surgery 6. patient with severe medical disease 7. Impossible to anticoagulation or anti arrhythmic drug
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| improvement of left ventricular function according to the rhythm control in patient with heart failure and new onset atrial fibrillation | 1 year | ejection fraction change (echocardiography) |
| functional capacity according to the rhythm control in patient with heart failure and new onset atrial fibrillation | 1 year | peak VO2 (cardio pulmonary test ; CPX) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| remodeling of atrium by the new onset AF in heart failure patients The change of LV function and functional capacity according to the rhythm in patients with HF and new onset AF | 1 years late | Echo cardiography (LV ejection fraction, LV wall thickness, LV mass index, LA dimension, LA appendage velocity, E/E'), EKG, 24 hours Holter recording |
| remodeling of ventricle by the new onset AF in heart failure patients The change of LV function and functional capacity according to the rhythm in patients with HF and new onset AF | 1 years late | Echo cardiography (LV ejection fraction, LV wall thickness, LV mass index, LA dimension, LA appendage velocity, E/E'), EKG, 24 hours Holter recording |
Countries
South Korea
Contacts
Primary ContactHui-Nam Pak, MD
Outcome results
None listed