Pregnancy
Conditions
Brief summary
The purpose of this study is to establish a tissue and data repository consisting of samples of human placentas, umbilical cord blood, and maternal blood, collected at the time of delivery. Specimens will be used in cellular, molecular, and functional studies to learn more about changes in placental structure and function, which can result in serious pregnancy complications and determine life-long health by programming the fetus for future metabolic and cardiovascular disease.
Interventions
None listed
Sponsors
University of Colorado, Denver
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy women delivering at term * Women with pregnancy complications such as: * pre-term birth, * intrauterine growth restriction, * diabetes, and * obesity.
Exclusion criteria
* Women: * under stress, * experiencing pain of labor. * Pregnancies complicated by other pathologies.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Collecting, processing, and archiving human specimens from 1250 subjects | Specimens will be stored for 50 years in repository | Human placental tissue, umbilical cord blood, and maternal blood samples will be collected from pregnant women at the time of their delivery. The samples will be used to enhance understanding of the role of the placenta in the development of pregnancy complications and in programming of adult disease. |
Countries
United States
Contacts
CONTACTAnita Kramer
PRINCIPAL_INVESTIGATORThomas Jansson, MD, PhD
University of Colorado, Denver
Outcome results
None listed