Diabetes Mellitus, Type 2
Conditions
Keywords
Exercise, Training, Interval training, Systemic inflammation, Glucose disposal, Insulin sensitivity, Glucose effectiveness
Brief summary
Interval training is superior to continuous training for improving glycemic control, hereunder glycemic variability and -spikes. However, the underlying mechanisms and the clinical impact is at present unknown. The overall objective of this project is to determine the mechanisms underlying aeroic interval-training-induced reductions in glycemic variability and -spikes, and the impact on levels of systemic inflammation in type 2 diabetes patients. It is hypothesized that aerobic interval training reduces glycemic variability and -spikes more than continuous training due to larger improvements in both peripheral insulin sensitivity and the mass action effect of glucose. Moreover, it is hypothesized that these reductions in glycemic variability and -spikes also reduces systemic inflammation.
Interventions
Sponsors
Rigshospitalet, Denmark
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Type 2 diabetes mellitus * BMI \>18 but \<40 kg/m2
Exclusion criteria
* Pregnancy * Smoking * Contraindication to increased levels of physical activity * More than moderate levels of physical activity (\>90 min/week) of maximally moderate intensity * Insulin dependence * Thyroid, liver, lung, heart or kidney disease, with the need for treatment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Glycemic control | Change from baseline at 14 days | Glycemic control incl. glycemic variability and -spikes, will be measured with continuous glucose monitoring over 24 hours during standardized dietary intake before and after each intervention. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Urinary isoprostanes as a measure of systemic inflammation | Change from baseline at 14 days | Systemic inflammation will be measured as isoprostanes in urine collected over 24 hours. The changes in glycemic control (Outcome 1), will be correlated with the changes in systemic inflammation. |
| Rate of dissappearance during a 2-step (pancreatic + hyperinsulinemic) hyperglycemic clamp, as a measure of glucose effectiveness + insulin sensitivity | Change from baseline at 14 days | A 2-step (pancreatic + hyperinsulinemic) hyperglycemic clamp will be performed before and after each intervention, to assess the mechanisms behind the intervention-induced improvements in glycemic control. In this way, the intervention-induced effects on glucose effectiveness and insulin sensitivity will be assessed. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Resting energy expenditure and respiratory exchange rate | Change from baseline at 14 days | Resting indirect calorimetry measurements will be performed before and after each intervention, to assess the effects of the interventions on resting energy-expenditure and respiratory exchange rates. |
Countries
Denmark
Outcome results
None listed