Immunosuppression, Sepsis
Conditions
Brief summary
The current project was designed to examine the express TIM-3 on lymphocytes and monocytes and its role in immunosuppression during sepsis.
Detailed description
Immunosuppression is the leading cause of death in septic patients.Lymphocyte apoptosis has been recognized as an important step in the pathogenesis of sepsis. Previous studies indicated that T cell immunoglobulin and mucin protein 3 (TIM-3) is a type I cell surface protein and was identified as a marker of lymphocyte dysfunction. The current project was designed to examine the express TIM-3 on lymphocytes and monocytes and its further role in immunosuppression during sepsis.
Interventions
None listed
Sponsors
Changhai Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* patients with severe sepsis * patients undergo invasive spine surgery * healthy volunteers
Exclusion criteria
* patients with immunodeficient diseases * patients who accept glucocorticoid or immunosuppressant * patients with an age older than 18 years * patients providing the informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| TIM-3 expression on CD4+, CD8+ T cells and CD14+ monocytes | within 24h after recruitment | TIM-3 level on T cells was compared between different populations. |
Secondary
| Measure | Time frame |
|---|---|
| 28-day mortality | 28 days after diagnosis of sepsis |
Countries
China
Contacts
Primary ContactLulong Bo, M.D., Ph.D.
Outcome results
None listed