Rapid Ligating the Corresponding Inflow and Outflow Vessels Without Hilus Dissection During Hepatectomy

A Simple Technique of Rapid Ligating the Corresponding Inflow and Outflow Vessels Without Hilus Dissection During Hepatectomy

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02319863

Enrollment

600

Registered

2014-12-18

Start date

1994-02-28

Completion date

2014-12-31

Last updated

2014-12-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer Progression

Keywords

hepatocellular carcinoma, prognosis

Brief summary

This study examines the role of this simple technique on postoperative metastasis and long term survival.

Detailed description

The only hope of long-term survival for patients with primary hepatocellular carcinoma (HCC) is surgical resection or liver transplantation, the former of which is more feasible at present. However, postoperative recurrence or metastasis is an ominous feature for this disease. Innovation of the surgical procedure for improving prognosis is under emergency request. This study examines the role of this simple technique on postoperative metastasis and long term survival. During the past 20 years, more 600 patients with primary HCC were performed hepatectomy with the new hemorrhage control technique, and prospective randomized controlled trial (RCT) was applied. We further applied a mice model ligating the pedicle of the lesion-located hepatic lobe before hepatectomy to imitate the clinic practice, and evaluated the role of the new technique on postoperative metastasis and survival.

Interventions

PROCEDUREhepatectomy (conventional method)

A Simple Technique of Rapid Ligating the Corresponding Inflow and Outflow Vessels Without Hilus Dissection During Hepatectomy

PROCEDUREhepatectomy (rapid ligating)

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* HCC patients who will perform left- or right- hemihepatectomy.

Exclusion criteria

1. contraindication for hepatectomy, including gastrointestinal hemorrhage, severe hemorrhagic disorders, explicit acute nonspecific infectious lesion, overt ascites, Child-Pugh Score C,indocyanine green retention rate at 15min (ICGR15)\>30%,serum hepatitis B virus (HBV)-DNA\>106 copies/ml and serum alanine aminotransferase (ALT)\>2×ULN, serum triglycerides\>2.0 mmol/L, circulatory shock, stroke, acute myocardial infarction, renal failure, coma of unknown cause; 2. pregnancy; 3. age of\<18y or\>65y

Design outcomes

Primary

Measure	Time frame	Description
recurrence	12 months	to examine if there is intrahepatic recurrence
metastasis	12 months	to examine if there is intrahepatic metastasis and metastasis in distant organs
mortality	1 month	intraoperative death， and death in one month after surgery

Secondary

Measure	Time frame	Description
Prognosis	5 years	to check the 5 years overall survival (OS) and disease free survival (DFS)

Countries

China

Contacts

Primary ContactXiaoping Chen, M.D.

chenxp@medmail.com.cn+86 27 83662851

Backup ContactBinhao Zhang, M.D.

bhzhang8@gmail.com+86 15802726021

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026