Gastroesophageal Reflux Disease (GERD), Non-erosive Reflux Disease (NERD)
Conditions
Keywords
reflux, GERD, EGD, pH testing
Brief summary
Gastroesophageal reflux disease (GERD) is a common condition affecting more than 100 million adults in the U.S., and it significantly impacts patients' quality of life while imposing billions of dollars of direct and indirect costs each year upon our healthcare system. Current diagnostic tests for GERD are highly invasive and medically inadequate, and the goal of this project is to develop a novel, minimally invasive Mucosal Impedance technique for more accurate detection of GERD while reducing costs.
Interventions
PROCEDUREStandard of Care esophagogastroduodenoscopy (EGD) with mucosal impedance testing
Sponsors
Vanderbilt University Medical Center
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients undergoing standard of care EGD with 48-hr pH testing by BRAVO * Previous diagnosis of reflux * At least 18 years of age
Exclusion criteria
* Those less than 18 years of age * Unable to give informed consent * Use of acid suppressive therapy within the last 10 days * Known history of Barrett's esophagus, gastric surgery, alcoholism, or significant motility condition
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measurement of lower esophageal impedance using mucosal impedance catheter | During standard of care EGD | Mucosal impedance is obtained during routine care EGD and readings are compared to 48-hour Bravo capsule results. Mucosal impedance only takes one minute to perform during endoscopy. |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORMichael Vaezi, MD, PhD
Vanderbilt University Medical Center
Outcome results
None listed