Stockholm Myocardial Infarction With Normal Coronaries (SMINC)-2 Study on Diagnosis Made by Cardiac MRI

Conditions

Myocardial Infarction

Brief summary

Myocardial infarction with angiographically normal coronary arteries (MINCA) is common (7-8 % of all myocardial infarctions). There are several different causes behind MINCA where true infarction due to thromboembolism, myocarditis or Takotsubo stress cardiomyopathy are the main findings. The underlying diagnosis is often made by clinical findings sometimes with the help of cardiac MRI (CMR). Investigators have previously shown that it was possible to give 50 % of the patients a diagnosis made by the combination of clinical findings and CMR made in median 12 days after the acute event. The present study aim at improve the diagnostic accuracy by an early CMR with latest technique.

Detailed description

The present study aim at improve the diagnostic accuracy in MINCA with an CMR made 2-4 days after the acute event. The aim is to give 70 % of all patients with MINCA (35-70 years old) a definitive diagnosis made by CMR only. One-hundred and fifty patients will be included and compared with a similar historical sample where 50 % of the patients received a diagnosis made by a late CMR and clinical findings. The study has 80 % power to detect this 20 % absolute difference (p \<0.05).

Steffen Johansson R, Tornvall P, Sörensson P, Nickander J.

2023-12-137 citations

10.1038/s41598-023-49223-w

Early Comprehensive Cardiovascular Magnetic Resonance Imaging in Patients With Myocardial Infarction With Nonobstructive Coronary Arteries.

Sörensson P, Ekenbäck C, Lundin M, Agewall S, Bacsovics Brolin E, Caidahl K, Cederlund K, Collste O, Daniel M, Jensen J, Y-Hassan S, Henareh L, Hofman-Bang C, Lyngå P, Maret E, Sarkar N, Spaak J, Winnberg O, Ugander M, Tornvall P.

2021-04-1467 citations

10.1016/j.jcmg.2021.02.021

The value of a new cardiac magnetic resonance imaging protocol in Myocardial Infarction with Non-obstructive Coronary Arteries (MINOCA) - a case-control study using historical controls from a previous study with similar inclusion criteria.

Tornvall P, Brolin EB, Caidahl K, Cederlund K, Collste O, Daniel M, Ekenbäck C, Jensen J, Y-Hassan S, Henareh L, Hofman-Bang C, Lyngå P, Maret E, Sarkar N, Spaak J, Sundqvist M, Sörensson P, Ugander M, Agewall S.

2017-07-2412 citations

10.1186/s12872-017-0611-5

Interventions

PROCEDURECMR

Intervention performed 2-4 days after admission to hospital with the latest CMR technique including sensitive oedema sequences using T1 mapping

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

SINGLE (Investigator)

Eligibility

Sex/Gender

ALL

Age

35 Years to 69 Years

Healthy volunteers

No

Inclusion criteria

* 35-70 years * Fullfill the diagnosic criteria of myocardial infarction * Normal coronary angiography or minor atheromatosis * Sinus rythm on ECG at admission

Exclusion criteria

* Previous myocardial infarction * Known cardiomyopathy * Pacemaker or claustrophobia * Severe chronic obstructive lung or kidney disease * Pulmonary embolism

Design outcomes

Primary

Measure	Time frame	Description
Diagnostic accuracy of an early CMR with the latest technique	2-4 days after admission	Show that the more patients get a definite diagnosis (70%) when compared to a historical sample (50%)

Secondary

Measure	Time frame	Description
Number of patients with correct diagnosis with echocardiography	12 months	To study the accuracy of echocardiography compared to CMR using ROC
Number of patients with a postive CT angiography and infarction on CMR	1 month	To study CT angiography findings in relation to myocardial infarction shown by CMR
Describe QoL over time	12 months	—

Countries

Sweden

Outcome results

None listed