Serum Vitamin D Level and Its Association With Ovarian Reserve and IVF Outcome

Conditions

VITAMIN D Disorders

Keywords

serum vitamin D levels, IVF, ovarian reserve, 25 OHD3, pregnancy outcome

Brief summary

Vitamin D has a major play in bone and calcium metabolism. Vitamin D deficiency (below 20 ng/ml) has also been linked to adverse health outcomes such as malignancy, cardiovascular disease, immune functioning, and glucose metabolism. Recent data from retrospective and prospective trials have demonstrated contradictive results concerning the role of vitamin D in female reproduction and IVF outcome. Some studies have found that women deficient in vitamin D had lower ovarian reserve and significantly lower clinical pregnancy rates when compared to patients who were sufficient levels in vitamin D. Some studies also demonstrated that serum 25-OH-D3 levels correlates with antimullerian hormone (AMH) levels in women of advanced reproductive age. It may also have a role to play in endocrine dysfunction and abnormal folliculogenesis in polycystic ovaries . The aim of this prospective cohort study including infertile women undergoing IVF treatment is to investigate the association between serum 25-OH- D3 levels and parametres of ovarian reserve (AMH, antral follicle count, number of oocytes collected) and clinical pregnancy and miscarriage rates .

Detailed description

Vitamin D has a major play in bone and calcium metabolism. Vitamin D deficiency (below 20 ng/ml) has also been linked to adverse health outcomes such as malignancy, cardiovascular disease, immune functioning, and glucose metabolism. Recent data from retrospective and prospective trials have demonstrated contradictive results concerning the role of vitamin D in female reproduction and IVF outcome. Some studies have found that women deficient in vitamin D had lower ovarian reserve and significantly lower clinical pregnancy rates when compared to patients who were sufficient levels in vitamin D. Some studies also demonstrated that serum 25-OH-D3 levels correlates with antimullerian hormone (AMH) levels in women of advanced reproductive age. It may also have a role to play in endocrine dysfunction and abnormal folliculogenesis in polycystic ovaries . The aim of this prospective cohort study including infertile women undergoing IVF treatment is to investigate the association between serum 25-OH- D3 levels and parametres of ovarian reserve (AMH, antral follicle count, number of oocytes collected) and clinical pregnancy and miscarriage rates .

Related papers

No related papers found yet.

Interventions

OTHERmonitor reproductive outcome

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 42 Years

Healthy volunteers

Yes

Inclusion criteria

* Subfertile women, * Indication for IVF, * 20-42 yrs of age.

Exclusion criteria

* Women on therapeutic supplementation for Vitamin D Deficiency, * Recurrent high order implantation failure

Design outcomes

Primary

Measure	Time frame
Clinical pregnancy rate	14 days post oocyte retrieval

Secondary

Measure	Time frame
AMH (antimullerian hormone) Levels	day 2-3 of the index cycle
AFC (antral follicle count)	DAY 2-3 OF INDEX CYCLE
Number of oocytes retreived	Two weeks from the last menstrual period

Countries

United Arab Emirates

Outcome results

None listed