Anesthesia, Cerebral Revascularization, Stroke
Conditions
Brief summary
Patients suffering a stroke with a large vessel occlusion is often treated intra veneous thrombolyse and on top of that also intra arterial therapy. It is unknown what form of anaestesia is best during intra arterial therapy. The investigators will randomize these patients between general anaestesia and local anaestesia. Outcome will be growth of the ischemic lesion as judged on an MRI scan.
Interventions
PROCEDURELocal anesthesia
Conscious sedation
Sponsors
Aarhus University Hospital
University of Aarhus
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* NIHSS\>10 * mRS=\<2 * groin puncture\<6hours from stroke onset * occlusion of ICA, ICA-T, M1, M2
Exclusion criteria
* MRI contraindications * GCS\<9 * intubated prior to arrival * posterior circulation stroke * allergy to anestetics
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Growth of DWI lesion | 48-72 hours |
Secondary
| Measure | Time frame |
|---|---|
| Time from arrival to groin puncture and recanalization | 1-2 hours |
| Blood pressure during intervention | 1-2 hours |
| Modified Rankin Score | 90 days |
Countries
Denmark
Outcome results
None listed