Paroxysmal Atrial Fibrillation, Sick Sinus Syndrome
Conditions
Keywords
sick sinus syndrome, paroxysmal atrial fibrillation, atrial pacing, high atrial base rate pacing
Brief summary
This study aims to determine whether increasing atrial base rate pacing to achieve at least 75-80% atrial pacing in patients with sick sinus syndrome undergoing the implementation of dual-chamber pacemaker can be useful to prevent or decrease the atrial fibrillation during 6 months follow-up duration.
Interventions
DEVICEHBR
DEVICEDD
Sponsors
Urmia University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Sick sinus syndrome patients having dual-chamber pacemaker * Having paroxysmal AF defined as at least 2 episodes of AHR/AMS \>190 b/min lasting \>6 minutes * Having normal atrioventricular conduction
Exclusion criteria
* Other clinical indications for pacing except sick sinus syndrome (bradycardia-tachycardia syndrome) * History of acute coronary syndrome * Significant heart valve disease * Chronic AF before randomization * Overt heart failure * Malignancy * Any reasons for antiarrhythmic medication use * Inability to follow patients every 3 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Atrial high rate/Automatic mode switch episodes | During 6 Months | The number of AHR/AMS episodes recorded by pacemaker |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Death | During 6 months | Death |
| Heart failure | During 6 months | The development or progression of heart failure during follow-up |
| Worsening Functional Class | During 6 months | The worsening of functional class |
| Stroke | During 6 months | The development of stroke during follow-up |
| Myocardial infarction | During 6 months | The development of MI during follow-up confirmed by ischemic chest pain, 12-ECG, or cardiac enzyme elevation |
Countries
Iran
Outcome results
None listed