Chronic Periodontitis
Conditions
Brief summary
This study will determine whether the supplemental use of chemical pocket disinfection with scaling and root planing is more effective than scaling and root planing alone in clinically reducing periodontal probing depth (PD), reducing bleeding on probing (BOP), and gaining clinical attachment level (CAL). It also will assess whether chemical pocket disinfection with scaling and root planing will have an effect on biomarkers of inflammation.
Detailed description
The purpose of this study is to determine whether the adjunctive use of chemical pocket disinfection with scaling and root planing is more effective than scaling and root planing alone in clinically reducing periodontal probing depth (PD), reducing bleeding on probing (BOP), and gaining clinical attachment level (CAL). It also will assess whether chemical pocket disinfection with scaling and root planing will have an effect on biomarkers of inflammation, as indicated by presence of pro- and anti-inflammatory cytokines, compared to scaling and root planing alone. The chemical pocket disinfection therapy consists of delivering a sodium hypochlorite solution followed by a neutralizing citric acid solution to the test site. Pro-inflammatory interleukin-1 beta and anti-inflammatory interleukin-1 receptor antagonist will be measured from the gingival crevicular fluid sampled from sites of interest.
Interventions
PROCEDUREScaling and root planing
Mechanical instrumentation
PROCEDUREScaling and root planing with solution
Mechanical instrumentation with sodium hypochlorite disinfective solution
Sponsors
University of Nebraska
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
30 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Periodontal maintenance patients, have at least one pocket greater than or equal to 5 mm with bleeding on probing
Exclusion criteria
* Uncontrolled diabetics * Regular users of nonsteroidal antiinflammatory drugs * Individuals on anti-coagulants * Individuals that have used antibiotics in the previous 3 months or require prophylactic antibiotic coverage * Pregnant individuals
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Probing depths | 3 months | Periodontal probing depth (PD) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Bleeding on probing | 3 months | Incidence of bleeding during probing |
| Clinical attachment level | 3 months | Clinical attachment level is calculated by adding gingival recession to probing depth; measures the connective tissue and epithelial attachment level relative to the cementoenamel junction |
| Inflammatory markers | 3 months | Measure interleukin-1 beta and interleukin 1 receptor antagonist levels in gingival crevicular fluid from sites of interest |
Countries
United States
Outcome results
None listed