Bronchiolitis Obliterans Syndrome
Conditions
Keywords
Helium, MRI, Lung transplantation
Brief summary
This study is a prospective, non-randomized, longitudinal, observational study that will recruit about 5 lung transplant patients per year for 3 years.
Detailed description
This study is a prospective, non-randomized, longitudinal, observational study that will recruit about 5 lung transplant patients per year for 3 years. We will follow these patients at 6 months and 1 year with Hyperpolarized Helium-3 Magnetic Resonance Imaging and image guided bronchial biopsies to detect early BOS and to better understand BO disease progression. The biopsies will provide future research for rapid determination of cellular and molecular mechanisms that lead to BOS and to facilitate identification and validation of translatable pharmaceutical targets.
Interventions
DRUGHyperpolarized Helium-3 MRI
Subjects will inhale Hyperpolarized Helium-3 gas during the MRI. This gas enhances images and the data collected will be used to determine if it can be used to detect BOS earlier than current standard of care.
Sponsors
Children's Hospital Medical Center, Cincinnati
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Years to 25 Years
Healthy volunteers
No
Inclusion criteria
* Lung Transplantation within the last 10 years or being assessed for possible lung transplantation. * Male or female * 0 to 25 years of age.
Exclusion criteria
* Standard MRI
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Analysis of MRI imaging to detect BOS compared to biopsy | 3 years | Analysis of MRI imaging to detect BOS compared to biopsy |
Countries
United States
Outcome results
None listed