Anesthesia
Conditions
Brief summary
The study is to observe whether dexmedetomidine could reduce agitation during emergence from general anesthesia in patients undergoing retroperitoneal laparoscopic surgery.
Detailed description
Agitation during emergence is frequent after retroperitoneal urologic surgery. Dexmedetomidine is alpha-2 receptor agonist which shows sedative and algesic effect. In this study we will compare the effect of dexmedetomidine given by different protocols on emergence agitation.
Interventions
DRUGdexmedetomidine
an alpha-2 receptor agonist
OTHERloading dose
0.8ug/kg of dexmedetomidine is given in 10 minutes
OTHERsustaining dose
0.4ug/kg/min of dexmedetomidine is given
Sponsors
Air Force Military Medical University, China
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Patients scheduled for retroperitoneal laparoscopic surgery * Patients with written informed consent
Exclusion criteria
* Patients with difficulty of communication * Patients with risk of obstructive sleeping apnea syndrome
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Richmond Score | From end of sevoflurane inhalation to departure from PACU, an expected average of 1 hour |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cough score | From end of sevoflurane inhalation to departure from PACU, an expected average of 1 hour | — |
| Time to awake | From end of sevoflurane inhalation to departure from PACU, an expected average of 1 hour | time to open eyes to verbal command |
Countries
China
Outcome results
None listed