Alcohol Dependence
Conditions
Keywords
healthy volunteers, social drinkers, alcohol
Brief summary
The purpose of the research study of the K23 award is to develop a blood test that can check how much alcohol a person has consumed in the past few days. We will enroll heavy social drinkers who do not have alcohol-related problems but used to drinking 5 or more beers on a single occasion. Both men and women between ages 21 and 65 years can join the study. All participants must be of European decent.
Interventions
OTHERAlcohol administration; Placebo administration
consumption of 3 alcohol doses (2 regular and one placebo) each within 2h on separate days
Sponsors
University of Maryland, Baltimore
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
21 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Experienced binge drinking episode(s) (5 or more standard drinks for men and 4 or more standard drinks for women consumed in about 2 hours according to NIAAA definition) in the past 30 days
Exclusion criteria
* DSM-IV diagnosed alcohol dependence, other drug dependencies including nicotine dependence
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Validity of using serotonin transporter mRNA expression levels | Within 24 hours of blood sample collection and in archived blood samples from the same participant stores at -80 degrees celsius for a duration of 6 months or more from the collection date | Validity of using serotonin transporter mRNA expression levels in 5 HTTLPR:LL and rs 25531:AA genotype carriers, as a biomarker of alcohol consumption levels. |
Countries
United States
Outcome results
None listed