Delirium
Conditions
Brief summary
The level of acetylcholinesterase is suspected to correlate with postoperative delirium. The investigators therefore score patients once preoperatively and twice postoperatively with the german version of the delirium-score NuDESC (Nursing Delirium Screening Scale) and compare the results with the acetylcholinesterase activity, butyrylcholinesterase activity and the serum anticholinergic activity (SAA) at corresponding time points.
Interventions
None listed
Sponsors
Heidelberg University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Signed written informed consent * Elective surgery
Exclusion criteria
* Preexisting psychiatric or neurological disease * No surgery * Reduced level of consciousness
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change of acetylcholinesterase (U/l) | one day before surgery, 1-24h after surgery, 25-72h after surgery | change of acetylcholinesterase in units per litre |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| change of NuDESC | one day before surgery, 1-24h after surgery, 25-72h after surgery | change of nursing delirium screening score |
| change of medication | one day before surgery, 1-24h after surgery, 25-72h after surgery | change of medication, that could influence a delirium |
| ICD-codes of main disease | 25-72h after surgery | International classification of diseases-code of main disease |
| ICD-codes of coexisting diseases | 25-72h after surgery | International classification of diseases-codes of coexisting diseases |
Countries
Germany
Outcome results
None listed