Adolescent Idiopathic Scoliosis
Conditions
Brief summary
The purpose of this study is to identify potential markers for curve progression in adolescent idiopathic scoliosis (AIS). Despite its prevalence and impact on child health, the etiology of AIS and molecular mechanisms underlying its development and progression remain poorly understood. Clinical criteria and features cannot adequately predict which children, diagnosed with mild disease, will undergo subsequent curve progression requiring intervention. The investigators hypothesize that alterations in specific genetic markers will be correlated with the progression of AIS curves over time. Thus, these markers could be used in the future to develop a reliable, inexpensive and relatively non-invasive cell based diagnostic test to (1) predict spinal curve progression in AIS, (2) select patients likely to benefit from early surgical intervention, and (3) potentially screen for asymptomatic children at risk of developing idiopathic scoliosis.
Interventions
None listed
Sponsors
University of Colorado, Denver
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
10 Years to 13 Years
Healthy volunteers
No
Inclusion criteria
* Females aged 10-13 years * Diagnosed with mild-moderate spine deformity (Cobb angle 15-30 degrees)
Exclusion criteria
* Patients with scoliosis other than idiopathic * Trauma * Inflammatory disease * Malignancies * Diabetes * History of previous spine surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Scoliosis Curve Progression | 3 years | Cobb angle, disc wedging, vertebral body wedging, coronal balance, sagittal balance |
Countries
United States
Contacts
Primary Contactjiandong hao
Outcome results
None listed