Healthy Elderly Muscle, Anabolically Resistant Elderly Muscle
Conditions
Brief summary
The primary objective is to determine the effect of reduced activity on the stimulation of myofibrillar FSR with protein feeding in the elderly.
Detailed description
The primary objective is to determine the effect of reduced activity on the stimulation of myofibrillar FSR with protein feeding in the elderly
Interventions
DIETARY_SUPPLEMENTisolated whey protein
isolated whey protein
DIETARY_SUPPLEMENTmicellar whey protein
micellar whey protein
DIETARY_SUPPLEMENTglycine
glycine
DIETARY_SUPPLEMENTcitrulline
citrulline
Sponsors
Société des Produits Nestlé (SPN)
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
MALE
Age
65 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Must habitually complete a minimum of 5000 steps per day * Having obtained informed consent * Non-obese * Non-smoker
Exclusion criteria
* Aged \>80 years * Inability to comply with study procedures * Currently participating or having participated in another infusion trial during last 12 months * Any acute or chronic llness * History of neuromuscular problems * Medications known to affect protein metabolism * Individuals who complete fewer than 5000 steps per day * Individuals who have metal implants
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in myofibrillar fractional synthetic rate (FSR) | one day and 2 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| change in non-myofibrillar fractional synthetic rate (FSR) | baseline and one day of feeding | — |
| Capillary dilatation and blood flow | 2 weeks | Determine if inactivity reduces the feeding-induced increase in capillary dilation and nutrient delivery and whether citrulline rescues this in resistant muscle or augments it in the healthy muscle as measured by Definity infusion and contrast enhanced ultrasound (CEUS) |
Outcome results
None listed