Daily Protein Intake Distribution and MPS (ARCIII)

Effect of Balanced Daily Protein Distribution Supplemented With Whey Protein on Muscle Protein Synthesis in Overweight Older Men During Calorie Restriction and Exercise (ARC III)

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02315014

Enrollment

Registered

2014-12-11

Start date

2013-03-31

Completion date

2014-06-30

Last updated

2014-12-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Overweight

Brief summary

To determine whether a balanced total daily dietary protein distribution supplemented with whey protein during a weight-loss intervention will result in increased muscle protein synthesis

Interventions

OTHERwhey protein

whey protein.

OTHERplacebo

placebo.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

60 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

* Overweight/obese (BMI 27-40 kg/m2) * Non-smokers * Non-diabetic * No history of hyperlipidemia * Not taking medications thought to interfere with study * Considered generally healthy

Exclusion criteria

* Efforts to lose weight in previous 16 weeks * Hyperlipidemia * Blood pressure ≥ 140/90 mmHg * Smoking * Heart and other organ disease * Type 2 diabetes * Gastrointestinal disease * Orthopedic injury interfering with exercise * Use of certain medications (HRT, antihypertensives, diuretics, antiarythmia medications, antiresorptive agents, anabolic agents, hypoglycemic agents, and statins known to affect muscle i.e. Simvastatin and Zocor)

Design outcomes

Primary

Measure	Time frame	Description
muscle protein synthesis	up to 4 weeks	protein synthesis is evaluated in muscle biopsy tissue

Secondary

Measure	Time frame
body composition is evaluated using DEXA	up to 4 weeks

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026