Topical PDT Cream Without Irradiation Source in the Acne Treatment

Topical Application of 1.5% Butenyl ALA Without Light Source Irradiation in the Treatment of Acne: a Double Blinded Randomized Controlled Trial.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02313467

Enrollment

Registered

2014-12-10

Start date

2014-01-31

Completion date

2015-02-28

Last updated

2015-03-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acne, Photodynamic Therapy

Brief summary

In this study, the investigators are going to compare the clinical effect and safety of topical application of 1.5% Butenyl ALA cream formula without light source irradiation in the treatment of acne.

Interventions

DRUGTopical application of 1.5% Butenyl ALA

DRUGTopical application of sham control

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

19 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* mild to moderate acne vulgaris (Leeds revised acne grading system score 2-7) at baseline.

Exclusion criteria

* known pregnancy * lactation * any medical illness that might influence the results of the study * a history of oral acne medication or surgical procedure, including laser treatment, within 6 months of study enrollment * use of topical acne medication within 4 weeks of study enrollment.

Design outcomes

Primary

Measure	Time frame
Percent change of inflammatory acne lesions compared with baseline	12 week

Secondary

Measure	Time frame
Percent change of non-inflammatory acne lesions compared with baseline	12 week
Percent change of overall severity of acne lesions compared with baseline	12 week

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026