Healthy Subjects
Conditions
Brief summary
The aim of this study is to monitor iodine nutrition in Switzerland in order to inform the authorities regarding iodine content in iodized salt. As a proxy for the entire population the investigators will study school aged children, pregnant women and women of reproduction age.
Detailed description
In a national sample of school aged children (n=990), pregnant women (n=700) and women of reproductive age (n=700) urinary iodine will be determined in order to assess iodine nutrition in Switzerland. In addition, in both groups of women a blood sample will be taken for the determination of thyroid hormones, iron- and folate status. Questionnaires will be used for the determination of dietary iodine and salt intake as well as sociodemographic parameters.
Interventions
None listed
Sponsors
Federal Food Safety and Veterinary Office (Switzerland)
Isabelle Herter-Aeberli
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
6 Years to 44 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy * Living in Switzerland for at least 1 year * For pregnant women: singleton pregnancy
Exclusion criteria
* Major known medical illness: thyroid dysfunction, gastrointestinal or metabolic disorders and taking chronic medications * For women of reproductive age: pregnancy, breastfeeding * Use of X-ray or CT contrast agent or iodine containing medication within the past year
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Median urinary iodine concentration in school aged children, pregnant women and women of reproductive age | Baseline | analysis of urine samples |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Population mean thyroglobulin | Baseline | Analysis of venous blood samples. Assessed only in women |
| Population mean thyroid stimulating hormone | Baseline | Analysis of venous blood samples. Assessed only in women |
| Population mean thyroxine | Baseline | Analysis of venous blood samples. Assessed only in women |
| Median urinary sodium concentration | Baseline | — |
| Median urinary creatinin concentration | Baseline | — |
Other
| Measure | Time frame | Description |
|---|---|---|
| Intake of iodine in micro grams per day | Baseline | iodine intake assessed by food frequency questionnaire, only in women |
| Mean height of school aged children and women of reproductive age | Baseline | — |
| % of households with adequate iodine coverage | Baseline | Salt samples only collected from children (subgroup) |
| Mean weight of school aged children and women of reproductive age | Baseline | — |
| Median urinary fluoride | Baseline | Analyzed in urine samples from school aged children only. |
| Population mean folate status | Baseline | Analysis of red blood cell folate and plasma folate in venous blood samples. |
| Populations mean iron status | Baseline | Serum analysis: ferritin, transferrin receptor; in women of reproductive age and pregnant women. |
| Individual inflammatory state | Baseline | Serum analysis of CRP and AGP, analyzed only in women |
Countries
Switzerland
Outcome results
None listed