Grading Scale of Vitreous Haze in Patients With Uveitis Using Ultrasonography

Status

Withdrawn

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02311192

Enrollment

Registered

2014-12-08

Start date

2014-10-01

Completion date

2016-09-30

Last updated

2023-08-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Uveitis

Keywords

Vitreous Haze, Ocular ultrasound, B scan, Uveitis

Brief summary

This study is aimed at creation and validation of a vitreous haze scoring system using ultrasonography B-scan of the eye. Images will be obtained from patients with uveitis and quantification of inflammation will be done to create the scoring scale.

Detailed description

Patients with uveitis may present with Vitreous Haze (VH) resulting in obscuration of fundus details. VH is composed of cells and protein exudation and results in decrease visual acuity.The degree of VH is an important indicator of disease activity, severity and response to therapy in patients with uveitis. Color fundus images are commonly used to objectively document VH.

Interventions

DEVICEUltrasonography B-scan

The patient's eye will be anesthetized. The ultrasound probe will then be used to obtain images by keeping the probe in light contact with the eye.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

19 Years to 90 Years

Healthy volunteers

Inclusion criteria

* • Ability to provide written informed consent and comply with study assessments for the full duration of the study * Age 18 -90 years * Diagnosis of uveitis

Exclusion criteria

* • Patients with posterior segment complications including retinal detachment, choroidal detachment or hemorrhage * Patients with any intraocular foreign body or displaced intraocular lens * Patients with silicon oil filled eye or with gas tamponade. * Patients with vitreous hemorrhage * Patients with media opacity including visually significant cataract that precludes grading of VH based on fundus photography

Design outcomes

Primary

Measure	Time frame	Description
Inter-observer correlation for vitreous haze grading	1 year	Inter-observer correlation for vitreous haze (VH) grading will be assessed using number of eyes as the unit of measure as well as standardized grading scheme for VH

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026