Diabetes Mellitus, Type 2
Conditions
Brief summary
Endothelial dysfunction of conduit arteries plays an important role in the development of cardiovascular complications associated with type 2 diabetes. In order to propose targeted therapeutic approaches, this study aim to determine the mechanisms involved in endothelial dysfunction of conduit arteries in these patients.
Interventions
BIOLOGICALBlood samples
Blood samples will be performed at baseline and during endothelial stimulation by hand skin heating to quantify metabolites of NO, EETs, ET-1 and ROS
Sponsors
University Hospital, Rouen
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
\- Type 2 diabetic patients or control subjects or healthy volunteers
Exclusion criteria
* Macroangiopathy * Insulin treatment * Chronic kidney disease (eGFR\<60 ml/min/m²) * Hyperlipidemia (total cholesterol\>2.5 g/l) * Smoking habit \> 5 cigarettes/day * Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from Baseline in EET concentration during endothelial stimulation | 30 min from the beginning of hand skin heating |
Secondary
| Measure | Time frame |
|---|---|
| Change from Baseline in NO concentration during endothelial stimulation | 30 min from the beginning of hand skin heating |
| Change from Baseline in ET-1 concentration during endothelial stimulation | 30 min from the beginning of hand skin heating |
| Change from Baseline in ROS concentration during endothelial stimulation | 30 min from the beginning of hand skin heating |
Countries
France
Outcome results
None listed